Long-lived plasma cell (LLPC) theory - Similarities between CFS and Lupus?

It's hard to draw everything together without ending up with a huge post. I think the arguments are there in the thread - and in the Qeios paper, which has a thread.

It might be antibody related, but I think other possibilities deserve serious thought.
 
Might be off topic but I have managed to get my NK cells from 49/μL (2nd Aug) to 92/μl (2nd Sep) with a protocol of blueberries, zinc, vit D/C/E, high dose melatonin. I hope it keeps going up.

Next test on 17th Sep Wed. Results take 2W.
 
ryanc97 said:
Might be off topic but I have managed to get my NK cells from 49/μL (2nd Aug) to 92/μl (2nd Sep) with a protocol of blueberries, zinc, vit D/C/E, high dose melatonin. I hope it keeps going up.

Next test on 17th Sep Wed. Results take 2W.
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May I ask the reasoning behind this? I assume that this is related to dara (please correct me if I am wrong) - is your thinking that the difference between responders and non-responders lies in the NK cells themselves, rather than in some upstream process, so you want to get your NK cells as high as possible? Or is there some other reason for wanting high NK cells?

I had never paid much attention to my own NK cells until recently; looked at last test results and noted that I am at 283/μL Ab NK (CD56/16) and 21.8% NK cells (interestingly, t-cells are apparently slightly low?).
 
DHagen said:
May I ask the reasoning behind this? I assume that this is related to dara (please correct me if I am wrong) - is your thinking that the difference between responders and non-responders lies in the NK cells themselves, rather than in some upstream process, so you want to get your NK cells as high as possible? Or is there some other reason for wanting high NK cells?

I had never paid much attention to my own NK cells until recently; looked at last test results and noted that I am at 283/μL Ab NK (CD56/16) and 21.8% NK cells (interestingly, t-cells are apparently slightly low?).
Click to expand...

Well yes if NK cells are the predictor of response because of ADCC mediated CD38 cell killing then my logic is to boost NK cells as high as possible, then take Dara.

283 is pretty good.

From limited anecdotes it seems severity is not correlated to NK cell count (we saw this in the study already), I am an example, mine is 50 (super low) but I would classify as mild.

Also wondering if it really is low NK cells being a non responder subset... if you can boost them up.... are you still in the subset or not?
 
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