Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance, 2025, Ruiz de Lazcano et al

Long-COVID and postural orthostatic tachycardia syndrome: a preliminary comparison of neuropsychological performance

Aitana Ruiz de Lazcano, Paula Pérez-Núñez, Mercè Pallarès-Sastre, Maddalen García-Sanchoyerto, Irune García, Imanol Amayra

Purpose
The aim of the study is to analyze and compare the cognitive profile between 59 patients with long-COVID [LC; 30 of them with and 29 without a positive coronavirus disease 2019 (COVID-19) confirmatory test] and 31 patients with postural orthostatic tachycardia syndrome (POTS) and a matched group of 39 healthy control participants.

Methods
Participants were examined on a battery of neuropsychological tests, including verbal memory, visuospatial abilities, attention, processing speed, verbal fluency, working memory, and visual memory. Anxious–depressive symptomatology was also analyzed and then controlled for possible influence on cognitive performance.

Results
Patients with LC and POTS showed significantly lower performance compared with healthy peers. Differences on anxious and depressive symptoms were also found between the clinical and control groups, resulting in LC without a positive confirmatory test group exhibiting the highest rates of anxious symptoms. After controlling the effects of anxious–depressive symptomatology, the differences were eliminated for some of the cognitive variables, but additional differences were found between patients with LC and POTS after post hoc analysis.

Conclusions
Findings from the present study contribute toward the reinforcement of the evidence on cognitive alterations associated with LC and POTS. Anxious–depressive symptomatology has to be considered in both clinical groups since it could be affecting cognitive performance.

Link | PDF (Clinical Autonomic Research) [Open Access]

 

Makes zero sense however they want to sell this. It's completely circular and all it does is make people obsess over things that are either irrelevant nonsense of consequences of the problem, and eliminating the problem is the only way to fix them.

This is what the biopsychosocial ideology does, it ruins everything it touches. Even otherwise useful studies are turned useless because the rot just spreads and covers everything else.