Live vaccines and a wider effect

Have you seen this interesting article in The Conversation? Particularly of interest is the disproportionate effect that non-live vaccines have on girls.

https://theconversation.com/vaccine...cts beyond protecting against target diseases

 

Adjuvent effect ? May be particularly important for vaccines which provide longer term protection and have a higher load - tetanus / HPV etc

Status of female immune system function in childhood/ adolescence? Do we simply assume that it' s only in pregnancy that it modifies? ( Apologies in advance, i know very little about immune system parameters )

Interesting . It does seem weird that this has not been considered before - it seems basic if it has been observed ...

 

Case in point was a study of live versus killed poliovirus vaccine. It was found those who were given the live vaccine had a 3 times lower rate of T1D, compared to those given the killed vaccine. It is hypothesized that the live vaccine provides stronger cross-protection against coxsackievirus B4, a virus linked to triggering T1D.

 

I've spent some time trying to uncover how the DTP results may be spurious - different travelling patterns of parents, perhaps more likely to have deaths recorded due to increased health system participation. But the results have appeared in multiple regions and even in a randomised study, so I am starting to think maybe there is an issue with DTP specifically.

https://www.s4me.info/threads/live-vaccines-and-a-wider-effect.7672/reply?quote=135833

There does not seem to be consistent evidence that the OPV protects against T1D. Most studies have null rate ratios. for example:
https://ebn.bmj.com/content/ebnurs/7/4/121.full.pdf

In any case, given that a majority of polio cases around the world are now caused by vaccine-associated strains, I doubt we're going to start using OPV again.