James P Allison and Tasuku Honjo win Nobel prize for medicine

Wessely, White and Sharpe overlooked again...

https://www.theguardian.com/science...bel-prize-for-medicine?CMP=Share_iOSApp_Other

PS: I’m not sure this work has any direct implications for ME/CFS, where, as I understand it, if anything, we’re trying to dampen down immune reactivity.

 

This new WIRED article goes into much more detail about James Allison and his career and research from beginning to now. It's long, but quite interesting.

Meet the Carousing, Harmonica-Playing Texan Who Just Won a Nobel for his Cancer Breakthrough

"The war on cancer is not over; we have not achieved a full and total cure, and so far the handful of cancer immunotherapy drugs available have demonstrated robust and durable results in a minority of patients. But we have undeniably turned a corner in our understanding of the disease—what many scientists believe to be a “penicillin moment” in our quest for the cure.

The CTLA-4-blocking drug Ipilumimab, approved by the FDA in 2015, was the first of a new class of drugs called “checkpoint inhibitors” and the beginning of what researchers refer to as a tsunami of new cancer treatments. The pace of progress is staggering, such that we now recognize that what Allison discovered is not only the end of that 100-year scientific mystery, but also the the beginning of a new chapter in medicine. Already, new therapies such as CAR-T have essentially wiped out some forms of cancer; the newest checkpoint inhibitors have turned stage-four metastatic death sentences into full remission. This work has only just begun. And while it’s hopeful, it’s not hype."


https://www.wired.com/story/meet-jim-allison-the-texan-who-just-won-a-nobel-cancer-breakthrough/