The translation isn't all that great but not a bad article from Yahoo! news in Japan: https://translate.google.com/translate?hl=en&sl=auto&tl=en&u=https://news.yahoo.co.jp/feature/1117. A lot has been written about the Hikikomori culture in Japan, recluse people who have withdrawn from society. I often wonder how many of them have ME or another "invisible" disease. Definitely not all, but possibly most or at least a large plurality. Edit: Hikikomori, not Otaku; and I'm not saying there's a link, just that likely many among those counted as recluse by choice are actually sick and just miscategorized.