Is there evidence of demyelination in MECFS?

This is a tweet from Ashley Haugen (Ron Davis’ daughter) yesterday based on a presentation from Michael Jensen of Stanford at the MECFS meeting at Stanford. Would obviously be good to have a little more information here, but I thought there wasn’t any good evidence of demyelination in MECFS?

https://dura.stanford.edu/residents/michael-jensen.html

https://twitter.com/user/status/1567548013224284160

 

@Jaybee00

Here is what I have found about this question in the Canadian Consensus Criteria Overview, page 5, point #5 Neurological/Cognitive Manifestations:

"MRI studies reveal elevated numbers of irreversible punctuate lesions consistent with demyelination or edema, predominantly in the frontal lobes (27) and the subcortical areas (28):

https://www.mefmaction.com/images/stories/Overviews/ME-Overview.pdf

Please see the reference pages 19 and 20 in the CCC Overview for reference #'s 27 and 28.

( I would have included links to these studies, but there is a glitch when I go to do this)


There may be more discussion of this in the full text of the Canadian Consensus Criteria. I note from page 10 of the full text CCC that the eleven experts who authored this criteria, published in 2003, had seen over 20,000 ME patients by that time:

https://www.mefmaction.com/images/stories/Medical/ME-CFS-Consensus-Document.pdf

Hope this helps.