Is the key pathology of ME/CFS in bone marrow?

Creekside said:
I've learned, from teeth and various other pains, that I am really terrible at correctly identifying where the pain is located. I was sure the pain was from one tooth, but it turned out the neighbour was cracked. My present foot pain feels like it's coming from the top of the foot, but it's actually a cyst much lower down, pressing on a nerve there. I expect this misidentification of pain sources is common in humans. So, a poll about bone pain isn't likely to provide useful information.

I have had that "pain in my bones" feeling, but I had that before ME too, and I doubt that it was caused by problems in the bones. I think it's more likely something making the brain cells that process those nerve signals more sensitive.
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I agree. I learned the same thing when I had endometriosis. I seemed to have bladder pain when it was in fact coming from the pouch of Douglas.
 
Creekside said:
I've learned, from teeth and various other pains, that I am really terrible at correctly identifying where the pain is located. I was sure the pain was from one tooth, but it turned out the neighbour was cracked. My present foot pain feels like it's coming from the top of the foot, but it's actually a cyst much lower down, pressing on a nerve there. I expect this misidentification of pain sources is common in humans. So, a poll about bone pain isn't likely to provide useful information.

I have had that "pain in my bones" feeling, but I had that before ME too, and I doubt that it was caused by problems in the bones. I think it's more likely something making the brain cells that process those nerve signals more sensitive.
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I agree with this too. I had ME already before my very severe ME flu triggered onset. I assume the bone pain I felt was from the flu because I know the person that I caught the flu from. I was visiting their place and he said he was really sick with flu and aching bones.

The pain I felt in my shin bone was agonizing and it did feel like the it was in one spot within the bone marrow. A very painful drawing out pain. Never experienced it since or before that. I wouldn't want to experience that again. Whether the bone marrow is caught up in ME I don't know but it is good to hear thoughts about other possibilities even though it is all over my head. Lol.

Thanks for such a good post and I can relate to a lot of what you said.
 
Jaybee00 said:
I just posted this lupus preprint, which includes co-authors from UCL rheumatology @Jonathan Edwards which mentions (I think) that the spleen is a more important factor than bone marrow in Lupus.
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I despair really. These are people in my own deparment and they have clearly never heard of the work Jo Cambridge, Maria Leandro and I did 25 years ago, or indeed understood the reason why we started B cell depletion in lupus in the first place.

The abstract reads as if they understood no b cell immunology.

The spleen will be an important reservoir for short lived plasma cells but if there is a feedback loop there needs to be another arm - which is very likely long lived plasma cells in bone marrow. We explained all this clearly in several reviews in the 2000s but of course nobody reads literature from then.
 
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