Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet, 2020, Borghini et al

Sly Saint · Jan 12, 2021

Abstract
Alimentary nickel (Ni) may result in allergic contact mucositis (ACM), whose prevalence is >30% and may present with IBS-like and extra-intestinal symptoms. These symptoms are also frequent in endometriosis, and Ni allergic contact dermatitis has already been observed in endometriosis. Therefore, intestinal and extra-intestinal symptoms in endometriosis may depend on a Ni ACM, and a low-Ni diet could improve symptoms.

We studied the prevalence of Ni ACM in endometriosis and focused on the effects of a low-Ni diet on gastrointestinal, extra-intestinal, and gynecological symptoms. We recruited 84 women with endometriosis, symptomatic for gastrointestinal disorders. Thirty-one out of 84 patients completed the study. They underwent Ni oral mucosa patch test (omPT), questionnaire for intestinal/extra-intestinal/gynecological symptoms, and a low-Ni diet. Clinical evaluation was performed at baseline (T0) and after three months (T1). Twenty-eight out 31 (90.3%) patients showed Ni omPT positive results, with Ni ACM diagnosis, whereas three out of 31 (9.7%) patients showed negative Ni omPT. After three months of low-Ni diet, all gastrointestinal, extra-intestinal and gynecological symptoms showed a statistically significant reduction. Ni ACM has a high prevalence in endometriosis and a low-Ni diet may be recommended in this condition to reduce gastrointestinal, extra-intestinal and gynecological symptoms.
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https://pubmed.ncbi.nlm.nih.gov/32012984/

Subtropical Island · Jan 13, 2021

Took a glance at the abstract. Still not clear what they mean by IBS-like, given that there are a few different types of IBS and each person has a few different aspects to their symptoms too.

(I can see why you might use it as an abbreviation but have they defined the specific symptoms they mean at all? Do they mean diarrhoea? Or constipation? Or gas pain? Or other types of pain? Or nausea? Weight loss? Or various hard to pin down things like fatigue, irritability, ..? Are they including that syndrome where bowel movement is supposed to relieve the pain? Or do they just mean unexplained gastro problems?)

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Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet, 2020, Borghini et al

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Irritable Bowel Syndrome-Like Disorders in Endometriosis: Prevalence of Nickel Sensitivity and Effects of a Low-Nickel Diet, 2020, Borghini et al

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Subtropical Island Senior Member (Voting Rights)

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