Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise, 2019, Egana et al

Andy · Jul 28, 2019

Highlights

• Muscle oxygen extraction is greater during incremental exercise in type 2 diabetes.
• This is likely due to a reduced oxygen delivery to active muscles.
• Impaired microvascular blood flow reduces exercise capacity in type 2 diabaetes [sic].

Abstract
We tested the hypothesis that type 2 diabetes (T2D) alters the profile of muscle fractional oxygen (O2) extraction (near-infrared spectroscopy) during incremental cycle exercise. Seventeen middle-aged individuals with uncomplicated T2D and 17 controls performed an upright ramp test to exhaustion. The rate of muscle deoxygenation (i.e. deoxygenated haemoglobin and myoglobin concentration, Δ[HHb + Mb]) profiles of the vastus lateralis muscle were normalised to 100% of the response, plotted against % power output (PO) and fitted with a double linear regression model. Peak oxygen uptake was significantly (P < 0.05) reduced in individuals with T2D. The %Δ[HHb+Mb]/%PO slope of the first linear segment of the double linear regression function was significantly (P < 0.05) steeper in T2D than controls (1.81±0.61 vs 1.35±0.43). Both groups displayed a near-plateau in Δ[HHb+Mb] at an exercise intensity (%PO) not different among them. Such findings suggest that a reduced O2 delivery to active muscles is an important underlying cause of exercise intolerance during a maximum graded test in middle-aged individuals with T2D.
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Paywall, www.sciencedirect.com/science/article/pii/S156990481930151X
Sci hub, https://sci-hub.se/10.1016/j.resp.2019.103258

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Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise, 2019, Egana et al

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Influence of type 2 diabetes on muscle deoxygenation during ramp incremental cycle exercise, 2019, Egana et al

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