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Increased risk of chronic fatigue syndrome following psoriasis: a nationwide population-based cohort study, 2019, Tsai et al

Discussion in 'BioMedical ME/CFS Research' started by Andy, May 16, 2019.

  1. Andy

    Andy Committee Member & Outreach

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    Hampshire, UK
    Open access, https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-019-1888-1

    Fukuda selection criteria. I think this is the same group who have published several other similar papers.
  2. Mithriel

    Mithriel Senior Member (Voting Rights)

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    Problem with all these studies is they most likely predict chronic fatigue not ME. Chronic fatigue is not to be taken lightly but it is not the same and the confusion will not be helpful to anyone.

    I can see why a disordered immune system would lead to fatigue and it is an interesting study from that point of view.

    I developed psoriasis after decades of ME and have heard this is not unusual though I did not expect it! It gets worse and better in line with my ME.
  3. lansbergen

    lansbergen Senior Member (Voting Rights)

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    Me too.
  4. Forbin

    Forbin Senior Member (Voting Rights)

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    I was diagnosed with scalp eczema a couple of years prior to ME. This seemed to morph into a diagnosis of scalp psoriasis about 10 years after the onset of ME. Fortunately it is intermittent and confined to the scalp.

    It seems that people who have psoriasis are more likely to have Crohn's disease. I mention this because a study of the microbiome in MECFS found...

    I was also once diagnosed with chronic ulcerative colitis (after ME onset), but it seemed to vanish after a month on sulfasalazine, making the initial diagnosis questionable. On the other hand, my mother developed chronic ulcerative colitis in her 30's and had it for the rest of her life.

    I would not be surprised if some imbalance in the microbiome has something to do with all of this, including ME.
  5. duncan

    duncan Senior Member (Voting Rights)

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    That pesky immune dysfunction. I recently developed eczema on both hands. I was prescribed steroid ointment for it, and the doctor advised that I wear rubber gloves all the time to keep the ointment from coming off because, you know, it's my hands. I am not doing that because, you know, IT"S MY HANDS.

    The tie-in to ME certainly is curious.
    Last edited: May 16, 2019
    andypants, MEMarge and Forbin like this.
  6. mariovitali

    mariovitali Senior Member (Voting Rights)

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    Thank you @Andy for this. Added to my ever growing list of ME's possible connection with Liver/Gallbladder issues.

    @duncan @Forbin

    In yet one more coincidence (?) of connection with ME and disruption of Bile acid metabolism- as found by Dr. Naviaux and Maureen Hanson- it appears that Bile acids may be effective in treating psoriasis :



    IMHO, several researchers look at the Gut microbiome without wondering why on earth it is disrupted in the first place.

    Links :



    Last edited: May 17, 2019
  7. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

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    This group has been fishing in this data for positive correlations quite some time, publishing many manuscripts each on one particular finding. As far as I know, their set of hypotheses were not pre-published and if they were, most of these associations would be published in a single manuscript, not spread out over many.

    This leads to their papers being uninterpretable since they are just fishing for findings.

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