In vivo assessment of muscle mitochondrial function in healthy, young males in relation to parameters of aerobic fitness, 2019, Nieuwenhuizen et al

Andy · Jun 10, 2019

Abstract
Purpose
The recovery of muscle oxygen consumption (mVO2) after exercise provides a measure of skeletal muscle mitochondrial capacity, as more and better-functioning mitochondria will be able to restore (mVO2) faster to the pre-exercise state. The aim was to measure muscle mitochondrial capacity using near-infrared spectroscopy (NIRS) within a healthy, normally active population and relate this to parameters of aerobic fitness, investigating the applicability and relevance of using NIRS to assess muscle mitochondrial capacity non-invasively.

Methods
Mitochondrial capacity was analysed in the gastrocnemius and flexor digitorum superficialis (FDS) muscles of eight relatively high-aerobic fitness (VO2peak ≥ 57 mL/kg/min) and eight relatively low-aerobic fitness male subjects (VO2peak ≤ 47 mL/kg/min). Recovery of whole body VO2, i.e. excess post-exercise oxygen consumption (EPOC) was analysed after a cycling protocol.

Results
Mitochondrial capacity, as analysed using NIRS, was significantly higher in high-fitness individuals compared to low-fitness individuals in the gastrocnemius, but not in the FDS (p = 0.0036 and p = 0.20, respectively). Mitochondrial capacity in the gastrocnemius was significantly correlated with VO2peak (R2 = 0.57, p = 0.0019). Whole body VO2 recovery was significantly faster in the high-fitness individuals (p = 0.0048), and correlated significantly with mitochondrial capacity in the gastrocnemius (R2 = 0.34, p = 0.028).

Conclusion
NIRS measurements can be used to assess differences in mitochondrial muscle oxygen consumption within a relatively normal, healthy population. Furthermore, mitochondrial capacity correlated with parameters of aerobic fitness (VO2peak and EPOC), emphasising the physiological relevance of the NIRS measurements.
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Open access at https://link.springer.com/article/10.1007/s00421-019-04169-8

Jonathan Edwards · Jun 10, 2019

This looks like a useful method for looking at muscle respiration and mitochondrial function in ME. MR spectroscopy can measure more different things I think but near infra red would be much more practical for real time assessments.

JohnTheJack · Jun 10, 2019

Moderator note:
Posts on Alpha ketoglutarate moved to new thread
https://www.s4me.info/threads/alpha-ketoglutarate-for-mitochondrial-respiration-dysfunction.9909/#post-175618

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In vivo assessment of muscle mitochondrial function in healthy, young males in relation to parameters of aerobic fitness, 2019, Nieuwenhuizen et al

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In vivo assessment of muscle mitochondrial function in healthy, young males in relation to parameters of aerobic fitness, 2019, Nieuwenhuizen et al

Andy Committee Member

Jonathan Edwards Senior Member (Voting Rights)

JohnTheJack Moderator Staff Member

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