Review Impact of sphingolipids on protein membrane trafficking, 2023, Aguilera-Romero et al.

[SNT Gatchaman]

Impact of sphingolipids on protein membrane trafficking
Aguilera-Romero; Lucena; Sabido-Bozo; Muñiz

Membrane trafficking is essential to maintain the spatiotemporal control of protein and lipid distribution within membrane systems of eukaryotic cells. To achieve their functional destination proteins are sorted and transported into lipid carriers that construct the secretory and endocytic pathways. It is an emerging theme that lipid diversity might exist in part to ensure the homeostasis of these pathways. Sphingolipids, a chemical diverse type of lipids with special physicochemical characteristics have been implicated in the selective transport of proteins.

In this review, we will discuss current knowledge about how sphingolipids modulate protein trafficking through the endomembrane systems to guarantee that proteins reach their functional destination and the proposed underlying mechanisms.

Link | PDF (Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids)

 

[SNT Gatchaman]

Understanding the nature and function of sphingolipids in membrane trafficking is an immense challenge. Despite the exciting recent advances, the molecular mechanisms of action remain poorly explored and, as presented in this review, just a few works have studied the importance of sphingolipid diversity.

 

[FMMM1]

Think (disrupted) sphingolipids turned up in a (metabolite) study in ME/CFS a few years ago, can't recall the researcher (Jonas Bergquist?) but a search on this site would probably turn it up.