Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome, 2022, Cervia et al

Abstract

Following acute infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) a significant proportion of individuals develop prolonged symptoms, a serious condition termed post-acute coronavirus disease 2019 (COVID-19) syndrome (PACS) or long COVID. Predictors of PACS are needed. In a prospective multicentric cohort study of 215 individuals, we study COVID-19 patients during primary infection and up to one year later, compared to healthy subjects. We discover an immunoglobulin (Ig) signature, based on total IgM and IgG3 levels, which – combined with age, history of asthma bronchiale, and five symptoms during primary infection – is able to predict the risk of PACS independently of timepoint of blood sampling. We validate the score in an independent cohort of 395 individuals with COVID-19. Our results highlight the benefit of measuring Igs for the early identification of patients at high risk for PACS, which facilitates the study of targeted treatment and pathomechanisms of PACS.

Open access, https://www.nature.com/articles/s41467-021-27797-1

 

Moved post
Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome
https://www.nature.com/articles/s41467-021-27797-1


The lead author, or at least the last named author on the paper, Onur Boyman, was interviewed on BBC Radio 4, Inside Science, today. He mentioned a link between long covid & ME
(https://www.bbc.co.uk/sounds/play/m0013rp4
EDIT - the section on this study runs from the start to middle (1 to 17 minutes) of the program

 

There seems to be the suggestion that lower serum levels of IgG3 (and lower IgM levels) may be an important factor in the development of Long Covid. One of the strongest predictors of Long Covid in this study was a history of bronchial asthma (Odds Ratio 9.74 - pValue 0.003).

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https://www.nature.com/articles/s41467-021-27797-1


ETA: Realized I just pretty much repeated part of @Andy 's post of the abstract.

 

is there any research of any type on worsening of pwme after infection?

also, is there any research on igg subclass profiles for pwme? anecdotally i notice reports of 1 and 3 low.

 

I believe there have been studies suggestive of just that, back several years. Maybe Natelson or Peterson?

It would be an interesting poll. I am IgG deficient in one of the subclasses. Can't recall which.

 

So doesn't look good for those with asthma then...

Any comments on this study's quality?

Interesting in that perhaps a number of pwME have similar factors that have brought about ME post viral episode.

 

I couldn't find when this study started in relation to vaccines coming out

It seems this study would have carried on into the time when vaccines were available.

Does anyone know?

COVID vaccines were available in Canada by about mid December 2020. I think they were available somewhat earlier in the UK, Europe, and the US.

In Canada, those at highest risk were vaccinated first - seniors in residential care. And, maybe health care workers if my recall is correct. It appears no one over age 65 was included in this study.

Thanks.

 

Worrying. They thought people with asthma would be at high risk of serious disease but found this was not the case. Shame if they are at high risk of longcovid.