Sasha
Senior Member (Voting Rights)
I'll preface my question by saying that I don't really know what I'm talking about when it comes to bioscience, so what I say below may be drivel and may be misrepresenting what these scientists are saying, and that I only listened to/read this stuff with half a brain and a dodgy memory, but...
I've just been listening to Prof. Scheibenbogen's talk on ME/CFS in post-Covid patients, in which she said (I think) that she observed problems with mitochondria and with auto-antibody-producing B-cells.
I've also just been reading Dr Valter Longo's book (The Longevity Diet) on dietary interventions to promote longevity. He includes discussion of a five-day 'fasting mimicking diet' that provokes the body to break down (I think) both malfunctioning cells and mitochondria and replace them with healthy new ones. He's done an RCT of the diet with some success in patients with MS (an autoimmune condition, obviously).
I think there are other, less drastic ways to get the body to cannibalise cells, at least (e.g. taking diluted acetic acid (or diluted vinegar, which contains it), or prebiotics such as FOS that your gut microbes can use to produce it) but I'm not sure about mitochondria.
So! Are malfunctioning mitochondria and/or auto-immune cells likely to be useful targets for PwME, and have their been trials of this approach?
And what safe, non-drug interventions other than fasting might lead to the body getting rid of dodgy mitochondria and replacing them with healthy new ones?
(BTW, lots of warnings in the literature not to drink neat vinegar - you can burn your oesophagus.)
I've just been listening to Prof. Scheibenbogen's talk on ME/CFS in post-Covid patients, in which she said (I think) that she observed problems with mitochondria and with auto-antibody-producing B-cells.
I've also just been reading Dr Valter Longo's book (The Longevity Diet) on dietary interventions to promote longevity. He includes discussion of a five-day 'fasting mimicking diet' that provokes the body to break down (I think) both malfunctioning cells and mitochondria and replace them with healthy new ones. He's done an RCT of the diet with some success in patients with MS (an autoimmune condition, obviously).
I think there are other, less drastic ways to get the body to cannibalise cells, at least (e.g. taking diluted acetic acid (or diluted vinegar, which contains it), or prebiotics such as FOS that your gut microbes can use to produce it) but I'm not sure about mitochondria.
So! Are malfunctioning mitochondria and/or auto-immune cells likely to be useful targets for PwME, and have their been trials of this approach?
And what safe, non-drug interventions other than fasting might lead to the body getting rid of dodgy mitochondria and replacing them with healthy new ones?
(BTW, lots of warnings in the literature not to drink neat vinegar - you can burn your oesophagus.)
