PART 1 Here is a run down of what's been going on with me.... In January of this year I traveled to see Dr. Chheda at Open Medicine Clinic. She had me try taking Ultra Low Dose Naltrexone, but I had a very bad reaction to it after just 1 dose and had to stop taking it immediately. She then had me start taking a small dose of a beta blocker and that too caused bad side effects that I only realized the extent of once I had stopped taking it. Those were the only 2 treatments I tried and given they both failed I declined to try anything else. As far as the testing that Dr. Chheda ran on me, of all the blood tests (a ton!) the only thing that came back abnormal was my Complement C3 and Complement C4 levels. My C3 was only 30% of normal and my C4 was just a few points below normal range. Dr. Chheda never even mentioned these abnormalities to me, and I am the one who pursued them after reading up on it. I felt it was important that I see a doctor about it. I requested that Dr. Chheda send a referral to an immunologist in my state that I had chosen, and she did so. That is the last interaction I had with Dr. Chheda. At the beginning of August I saw the immunologist (Dr. A). He ran the following blood tests.. Complement C3: 40 (normal range: 87 - 200) LOW Complement C4: 13 (normal range: 13 - 50) Complement CH50: 30.5 (normal range: 41.7 - 95.1) LOW Complement AH50: 60% (normal range >or= 46%) Tryptase: 4.2 (normal range: 0.0 - 11) C1 Esterase Inhibitor (function): 85% (normal range: 68 - 100%) C1 Esterase Inhibitor (protein level): 19 (normal range: 22 - 43 mg/dL) LOW * Because my "function" level is normal there is no concern about my low "protein level" % CD4: 35 % (normal range: 33 - 61%) Abs CD4 Lymphocyte Cnt: 0.798 10*3/uL (normal range: 0.730 - 2.250 10*3/uL) % CD8: 41% (normal range: 14 - 35%) HIGH Abs CD8 Lymphocyte Cnt: 0.941 10*3/uL (normal range: 0.250 - 1.240 10*3/uL) % CD19+: 8% (normal range: 9 - 23%) LOW Abs CD19+ Lymphocyte Cnt: 0.192 10*3/uL (normal range: 0.160 - 0.390 10*3/uL) CD4/CD8 Ratio: 0.85 (normal range: 1.00 - 3.78) LOW % CD3: 83 % (normal range: 57 - 87%) Abs CD3+ Lymphocyte Cnt: 1.928 THOU/ul (normal range: 1.040 - 3.400 THOU/ul) * Even with these T-Cell Subset abnormalities the immunologist still considered my results normal and of no concern. Erythrocyte Sedimentation Rate: 8 (normal range: 0 - 20 mm/h) C-Reactive Protein: 0.3 (normal range: 0.0 - 10.0 mg/L) S. Pneumoniae IGG AB, 23 Serotypes: Normal Response Given my test results, and history of infections the immunologist felt confident that I do not have a primary immune deficiency although he did say that my low Complement is likely making me slightly more prone to bacterial infections (my medical history shows this) and to make sure to mention that I have "low complement" to doctors in the future and err on side of caution any time it's suspected I may have a bacterial infection. In terms of my Complement levels we established definitively that it is my Complement C3 and CH50 that are low. Even though my C4 level was slightly below normal range the first time it was tested my C4 levels have been within normal range (at low end of normal) the last 2 times tested and thus my C4 level is considered to be normal. This is important because having both low C3 and C4 points toward someone having low Complement as a result of an immune complex disease (aquired) rather than a congenital cause (genetic). The Dr. A then referred me to a colleague (Dr. K) of his who is a medical professor at the same hospital (a university teaching hospital) who specializes in both Immune Deficiency and Rheumatology and who is knowledgeable about the Complement System and Complement Deficiencies (these doctors are very hard to find).