ACTH test for my daughter found a good response, but low base hormone levels. I don't have a copy to know how low (done under endocrinologist), but GP has said it was low but not overly low. I have requested a copy of results. My initial feeling was that if ATP and magnesium are low, then this would account for low base hormone levels as these are required for synthesis. ( i am not very science oriented but trying- probably in both senses of the word) Hydrocortisone has been prescribed 10mg tablet split into 2 doses daily and she has been taking this for 8 days. ( first two days we had 1/2 tablet spit into 2 ) My query is re effectiveness and side effects. As I am trying not to present as a completely neurotic mother at GP/hospital can anyone advise re the impact of these with ME? She is feeling much more fatigued- generally not able to turn over in bed til 10.30/11am sit up in bed til after 2pm ( this may reflect the sleep shift) Sleep phase shifted more ( sleeping later) Lymph glands swollen up ( but this happens a lot)- underarm lymphs very swollen predominantly on one side- lower immunity? Hips very sore ( she does get sore hips, this seems to be an intensification) Shoulders and neck sore - this is muscular ( she gets muscle " shlumps" - essentially muscles tight/ spasm at connection with " ribs" near shoulder blades and neck- area this is happening over is extended ( may of course have nothing to do with HC) Joints more sore Eyesight worse - but this may be due to increased tiredness She did feel positive after endocrinologist appointment as she felt that he would actually look at tings and do something - a novelty. Current experience is etting her down. We are waiting for appointment for MRI to check out pituitary/ hypothalamus If anyone has any experiences similar to this were they able to resolve them?