How to select trial participants with ME/CFS?

The idea would initially be at baseline w/o PEM—I’m fairly confident that at least some signature can be picked up outside of PEM.

I’m not married to this idea, I just sense that it might be a continuing problem even for finding a pathological mechanism if there’s no good way to select a relatively homogenous study group or identify subsets within a heterogenous study group.

Incidentally, the amino acid metabolism and utilization findings are driving my malate-aspartate shuttle pet theory, which I plan to keep pursuing. It’s just likely not going to be my PhD thesis since I’m in a lab with a computational focus—I’ll need another computationally focused project like a multi-omics analysis.

Unfortunately multi-omics is not well suited for hypothesis testing, so it would not be able to give me much more insight about any previous findings other than to just confirm them. But it is well suited for identifying existing patterns in the absence of a pathological mechanism