'Holy Grail' discovery could mean 'nobody needs to worry about their MS getting worse' – study

[Dolphin]

A “Holy Grail” molecular target has been discovered to protect nerves from damage in multiple sclerosis (MS), a study has said.

The paper, published in Acta Neuropathologica on Wednesday, also said that a common diabetes drug could help enhance this new-found natural mechanism and prevent disability progression in the neurological condition.

In MS the protective coating surrounding nerves known as myelin is damaged causing them to become less energy efficient which makes them vulnerable to further damage and causes disability over time, the MS Society said.

Following a research programme spanning more than a decade researchers at the University of Edinburgh, partly funded by the MS Society, discovered a natural mechanism in the body that tackles this issue, which they are calling ARMD (axonal response of mitochondria to demyelination).

Continues at:
https://www.irishexaminer.com/world/arid-40027451.html

Early days yet of course.

 

[Mithriel]

Plioglitazone is Actos. From diabetes.co.uk: after 1 year of use the risk of bladder cancer is increased by 83%. They also say it reduces insulin resistance so the hormone works better.

It does not mention that it changes bone stem cells so they make new fat cells (not usual in adults) which can store more sugar from the blood. This lack of bone stem cells leads to osteoporosis and a high rate of fractures.

A sister drug Avandia was banned after it was found that "the drug worked well except for doubling the risk of death from heart failure"

It was said at the time that the manufacturers of Actos learned a lot from this - they did not do any long term follow up studies!

It may be that the risks of side effects will have to be weighed against the drop in severity of MS but saying "a commonly used diabetes drug" glides over a lot of problems.

I was very disappointed when I discovered what the drug was as I would never take it for my diabetes.

 

[butter.]

Plioglitazone is Actos. From diabetes.co.uk: after 1 year of use the risk of bladder cancer is increased by 83%. They also say it reduces insulin resistance so the hormone works better.

It does not mention that it changes bone stem cells so they make new fat cells (not usual in adults) which can store more sugar from the blood. This lack of bone stem cells leads to osteoporosis and a high rate of fractures.

A sister drug Avandia was banned after it was found that "the drug worked well except for doubling the risk of death from heart failure"

It was said at the time that the manufacturers of Actos learned a lot from this - they did not do any long term follow up studies!

It may be that the risks of side effects will have to be weighed against the drop in severity of MS but saying "a commonly used diabetes drug" glides over a lot of problems.

I was very disappointed when I discovered what the drug was as I would never take it for my diabetes.

they should try a combination with cbt maybe!