HIV vaccine succeeds in Phase 1 trial

[RedFox]

Vaccination induces HIV broadly neutralizing antibody precursors in humans
https://www.science.org/doi/10.1126/science.add6502

Human vaccination induces bnAb precursors
Each year, more than 1 million new HIV infections occur, highlighting the need for effective HIV vaccines. Vaccine strategies that induce broadly neutralizing antibodies (bnAbs) have promise to combat HIV and other pathogens but have not yet been tested in humans. Leggat et al. report the results of a phase 1 clinical trial showing that a germline-targeting priming immunogen was safe and feasible and induced targeted bnAb-precursor responses in 97% of vaccine recipients at substantial frequencies in each individual (see the Perspective by Moore). bnAb-precursor responses made favorable gains in mutation and affinity after a booster vaccination. The results establish proof of principle for this reductionist vaccine approach and encourage the development of additional boosters to induce bnAbs. —PNK

 

[RedFox]

I'm gonna be sad if there's a vaccine for HIV, but I'm too sick to need it because there isn't a treatment for ME. I think that's likely.