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High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice, 2019, Peri-Okonny et al

Discussion in 'Health News and Research unrelated to ME/CFS' started by Webdog, Jan 17, 2019.

  1. Webdog

    Webdog Senior Member (Voting Rights)

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    Inorganic phosphate, an additive and preservative used in up to 70% of foods in the common American diet, may reduce the ability to exercise.

    Study:
    High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice
    Peri-Okonny et al, 2019
    https://dx.doi.org/10.1161/CIRCULATIONAHA.118.037550

    Articles:
    Common Food Additive Derails Good Exercise Habits
    https://neurosciencenews.com/food-additive-exercise-10475/

    Does this common food additive stop us exercising?
    https://www.medicalnewstoday.com/articles/324131.php
     
  2. Webdog

    Webdog Senior Member (Voting Rights)

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    Andy, ScottTriGuy and Snowflake like this.
  3. Webdog

    Webdog Senior Member (Voting Rights)

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    This was a 2 part study. That confused me at first. According to Medical News Today:
    1. In the mouse experiment, 12 weeks of following a phosphate-enriched diet correlated with less time on the treadmill and lower cardiac fitness in the rodents. The mice that consumed additional phosphate had an impaired fat-burning metabolism. Also, the researchers found that 5,000 genes that help process fat and aid cell metabolism were altered in these mice.
    2. In the second part of the study, Dr. Vongpatanasin and team examined data on over 1,600 healthy people. The participants had worn fitness trackers for 7 days, which allowed the scientists to monitor their exercise levels.
     
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  4. Snowdrop

    Snowdrop Senior Member (Voting Rights)

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  5. mariovitali

    mariovitali Senior Member (Voting Rights)

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    Very interesting study. Looking a bit into the text, shown in red rectangle we see PPARĪ³ aka PPARG :




    aaa.png



    I find interesting that we have -yet- another mention of peroxisome proliferators (PPARs) of which PPARĪ³ is part of in a recent study from NZ :


    https://www.s4me.info/threads/chang...-me-cfs-2019-sweetman-et-al.7694/#post-136218


    Going back to 2017, we see PPARG node selected in the Network Analysis :


    https://forums.phoenixrising.me/index.php?threads/machine-learning-assisted-research-on-cfs.51283/


    [​IMG]
     
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