High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice, 2019, Peri-Okonny et al

[Webdog]

Inorganic phosphate, an additive and preservative used in up to 70% of foods in the common American diet, may reduce the ability to exercise.

Study:
High-Phosphate Diet Induces Exercise Intolerance and Impairs Fatty Acid Metabolism in Mice
Peri-Okonny et al, 2019
https://dx.doi.org/10.1161/CIRCULATIONAHA.118.037550

Articles:
Common Food Additive Derails Good Exercise Habits
https://neurosciencenews.com/food-additive-exercise-10475/

Does this common food additive stop us exercising?
https://www.medicalnewstoday.com/articles/324131.php

Our data demonstrate a detrimental effect of dietary Pi (Inorganic phosphate) on skeletal muscle fatty acid metabolism and exercise capacity that is independent of obesity and cardiac contractile function. Dietary Pi may represent a novel and modifiable target to reduce physical inactivity associated with the Western diet.

 

[Webdog]

Dr. Vongpatanasin comments on the significance of the team's results, saying, "I think it might be about time for us to push the food industry to put this on labels so that we can see how much phosphate goes into our food."

https://www.medicalnewstoday.com/articles/324131.php

 

[Webdog]

This was a 2 part study. That confused me at first. According to Medical News Today:

1. In the mouse experiment, 12 weeks of following a phosphate-enriched diet correlated with less time on the treadmill and lower cardiac fitness in the rodents. The mice that consumed additional phosphate had an impaired fat-burning metabolism. Also, the researchers found that 5,000 genes that help process fat and aid cell metabolism were altered in these mice.
   
2. In the second part of the study, Dr. Vongpatanasin and team examined data on over 1,600 healthy people. The participants had worn fitness trackers for 7 days, which allowed the scientists to monitor their exercise levels.

 

[Snowdrop]

This might then be of interest on the topic:

https://safewater.zendesk.com/hc/en...ects-of-drinking-water-containing-phosphates-

ETA: Just noticed that your post says inorganic phosphates so maybe not the same thing.

 

[mariovitali]

Very interesting study. Looking a bit into the text, shown in red rectangle we see PPARγ aka PPARG :








I find interesting that we have -yet- another mention of peroxisome proliferators (PPARs) of which PPARγ is part of in a recent study from NZ :


https://www.s4me.info/threads/chang...-me-cfs-2019-sweetman-et-al.7694/#post-136218


Going back to 2017, we see PPARG node selected in the Network Analysis :


https://forums.phoenixrising.me/index.php?threads/machine-learning-assisted-research-on-cfs.51283/