So I have this new lab result, a mildly high alkaline phosphatase (ALP).
My doctor ran some tests, and thinks that because she was able to trace the enzyme to a bone type (yes, apparently bone can cause a liver enzyme test to be high), and it’s not parathyroid, it must be deconditioning.
I can’t actually find any evidence that deconditioning would cause this. I have been looking at causes and I found several things that weren’t tested, one of which would be a good fit for me.
Most comprehensive article I found on differential diagnosis:
http://www.clinicaladvisor.com/hospital-medicine/elevated-alkaline-phosphatase/article/600760/
When looking specifically for deconditioning and ALP, I found two articles on microgravity that specifically said ALP is not affected, or is downgraded (not increased).
Looks like high ALP is a risk in severely ill, inactive people (not seeing the link that says that right now), but if as a bone building disease it would be from low vitamin D, from lack of sunshine, parathyroid, or digestive issues.
She also told me there’s no treatment, but there is.
Just wanted to share what I found in case others run into the same issue.
This exercise as a panacea has to end. I am sure it’s great for healthy people (or 90% of healthy people anyway, but I lost that citation), but in ill people, pretty sure it’s a marker of how well/badly someone is doing, not a way to improve. Correlation isn’t causation.
My doctor ran some tests, and thinks that because she was able to trace the enzyme to a bone type (yes, apparently bone can cause a liver enzyme test to be high), and it’s not parathyroid, it must be deconditioning.
I can’t actually find any evidence that deconditioning would cause this. I have been looking at causes and I found several things that weren’t tested, one of which would be a good fit for me.
Most comprehensive article I found on differential diagnosis:
http://www.clinicaladvisor.com/hospital-medicine/elevated-alkaline-phosphatase/article/600760/
When looking specifically for deconditioning and ALP, I found two articles on microgravity that specifically said ALP is not affected, or is downgraded (not increased).
Looks like high ALP is a risk in severely ill, inactive people (not seeing the link that says that right now), but if as a bone building disease it would be from low vitamin D, from lack of sunshine, parathyroid, or digestive issues.
She also told me there’s no treatment, but there is.
Just wanted to share what I found in case others run into the same issue.
This exercise as a panacea has to end. I am sure it’s great for healthy people (or 90% of healthy people anyway, but I lost that citation), but in ill people, pretty sure it’s a marker of how well/badly someone is doing, not a way to improve. Correlation isn’t causation.