Golden hour (/month)

Here's a weird funfact:

November appears to be magic.

This time last year -- and now -- I'm experiencing a sudden surge of normalcy. Motivation to do tasks matched by the ability to actually do them! Last year I held a Thanksgiving party where I cooked for 25 people with marginal help. I got an enormous amount done at Stanford by setting a schedule for myself to complete a large number of tasks before I went home for Christmas.

And now it's happening again!

Now, here's the bad part.

There was a downturn starting in December that became one of my worst, slow-motion crashes of all time. I was essentially crashed for the first five weeks of the new year.

Did I do too much and that's the payback? Did the sudden surge of normalcy 'wear off' but I kept going, used to my new, expanded energy envelope? Was it unrelated? (I did become intolerant to one of the pills I relied on at that time, but talk about a chicken-or-egg problem!)

So: First, has anyone else noticed this? Especially with cooling temperatures?

Has anyone noticed an attendant surge of poor health once winter really settles in?

Very curious to see if anyone else has experienced this.

 

Sometimes I wonder if we are the same person Jaime.

Sadly, for once, my Autumn / November magic has so far been absent this year.

Slowly but steadily becoming more ill might explain the absence though. I am definitely dreading end of December / January though. Last year was absolutely brutal.

Personally I am sure the fluctuations I experience have nothing to do with the ''boom and bust cycle'' (I don't personally believe in the cycle generally for ME/CFS patients at all, and feel like it's another way to blame patients for causing their symptoms).

 

Yes. But for me it happened in the spring. But different situations maybe due to location? Winter (usually by Nov) means a lot of dry heat. Spring can be cool and I'd open all the windows (not longer possible now I've moved to a high rise apt).

 

@JaimeS . . . I feel energized starting mid September/October (eastern Canada)= cooler weather. The month of December I usually feel achy (fluey?) so a little less energy. I pick up again around February.

I feel at my worst starting April and figured out that it has to do with the start of allergy season. I don't have the normal allergy symptoms, but my immune system is affected, and every 2-3 years I come down with some major virus during this time.

 

The dysfunctional cognitions and maladaptive behaviour are entitled to a break too.

 

Yes. How odd. I am usually on guard for cold, as it is a trigger for many with periodic paralysis, which my wife has. Moreover, I have little tolerance for cold.

But almost without fail, late Autumn brings a semi-reprieve in my symptom severity.

Not sure if it's a rooster raising the sun sort of thing, though.

 

If you're in the southern hemisphere, then we are talking about the same type of weather/coolness probably.

Another yes. This is really interesting! Early February was when my bad period finally began to let up.

!!!!

That's one "no", as far as I'm concerned -- I can tell it's getting cooler and my body LOVES it.

People tend to think of California as "Los Angeles", but California is very large, and the northern half of it is no different from any other northern state. Mid-Cali is temperate and dry, and northern Cali is a typical Pacific Northwestern Forest, much like what you'd find in Washington state and even Canada. The days are, in fact, shorter, and it's cooler out.

And unless I miss my guess, my metabolism is ticking up. I'm also losing weight and running warmer.

 

That's five yeses and one no, I think.

Could be that this is A Thing -- yet another Thing That Patients Know & No One Else Has Ever Minded.

In which case, damn -- better gear up for December.

Any advice, brain trust?

 

OK, let me be more specific.

Can you describe what December & January feel like for you?

In my case I became intolerant to a pill I'd relied on for years. That could imply increased immune activation or increased gut permeability or both.

 

We shall all move to the Canary Islands.

Average temperature: 17 to 24 Celsius.

The Canary Islands have an excellent climate year round.

Summers are warm, but not so hot, and the winter is mild.

 

Booking the flight now.

________________

I'm going to drop some links here that I've found to be of interest. I'll post more as I think on things.

• Systems biology of circadian-immune interactions: https://www.ncbi.nlm.nih.gov/pubmed/23006670
• T-cell numbers and antigen-specific T-cell function follow different circadian rhythms: https://www.ncbi.nlm.nih.gov/pubmed/22797814
• Vitamin D status and its association with season, hospital and sepsis mortality in critical illness:https://www.ncbi.nlm.nih.gov/pubmed/24661739
• Seasonal immune modulation in humans: observed patterns and potential environmental drivers: https://www.ncbi.nlm.nih.gov/pubmed/25246360
• Neuroendocrine control of photoperiodic changes in immune function: https://www.ncbi.nlm.nih.gov/pubmed/25456047

• Seasonal effects on gene expression: https://www.ncbi.nlm.nih.gov/pubmed/26023781

• The role of the hypothalamic-pituitary-adrenal axis in modulating seasonal changes in immunity: https://www.ncbi.nlm.nih.gov/pubmed/27341833

• Seasonality and autoimmune diseases: The contribution of the four seasons to the mosaic of autoimmunity: https://www.ncbi.nlm.nih.gov/pubmed/28624334

• Genetic and phenotypically flexible components of seasonal variation in immune function: https://www.ncbi.nlm.nih.gov/pubmed/24436383

• Temporal control of glucocorticoid neurodynamics and its relevance for brain homeostasis, neuropathology and glucocorticoid-based therapeutics: https://www.ncbi.nlm.nih.gov/pubmed/26656793

• Circadian regulation of human peripheral neutrophils: https://www.ncbi.nlm.nih.gov/pubmed/27132055

[Edit: crossing 'em out as I delve]

 

OK, not much here except to say that Vit D, which tends to be low in the chronically ill in the first place, might drop even lower in the winter. This is not surprising. I'd be quite interested to monitor it over the course of November and December to see if it's getting any lower, as I take supplements.

This is a literature review that confirms that immune function drops in temperate climates in the winter, and during the rainy season in areas that happen to have one.

There were a few types of immune responses they looked for. For vaccinations, they found that the strongest immune response was -- you guessed it -- late summer through late fall, or in areas with a rainy season "just before the start of the rainy season" which fits with the increased wellness we're seeing as pwME. This implies that an uptick in immune function makes us feel better, which would put paid to the idea that our immune systems are operating wildly out of control.

A second study on Hep B vaccine also found that the highest immune responses were in October and November.

There seems to also be a general trend of a stronger immune response in the winter in comparison to the summer, but I want to see fall versus winter...

For skin-prick allergy testing, they also found that "late rainy season" in areas with a rainy season, and just before winter in temperate zones produced the strongest immune responses.

Live vaccines showed the same basic pattern of worse possibility for infection once winter had set in.

 

Unless you don't buy into the sun is supplementing our Vit D, so when it gets cold, we go out less, and by extension our Vit D values decline. Broadly speaking, for the healthy or acutely sick, sure. For those beset with chronic illness like us, I'm not so certain I get access to the sun any more when it's warmer than when it's colder.

 

Too generalized to be of use, I think, though worth noting they seem to be saying that immune function is upregulated in the winter, they are still comparing it to summer, and talking about many, many species.

Oh, man. I'm not enough of a statistician to judge the data-wrangling but, if true, this is fascinating.

Immune cell production peaks in late autumn! Monocytes, CD19 cells, and platelets are at an all-time high.

RBCs and neutrophils, on the other hand, seem to peak in late winter through early spring -- when we may do most poorly.

So, are the monocytes, CD19, and/or platelets things we need to support? Are neutrophils something we need to convince to 'chill out'?

Or some combo of both?

It's even possible that rather than a simple case of immune activation or immunosuppression, we have a more complex picture: being too high in summer, beginning to feel good as immune activation drops slightly as fall turns to winter, and ending in January with immune function generally suppressed. Nothing, especially in biology, is obliged to be simple.

 

I was waiting for someone to bring this up.

I went looking for papers on seasonal variation in sedentary humans or in the chronically ill and bedbound, but no luck on PubMed. Google Scholar, which has a slightly different search mechanism turned up something interesting: that people with MS have fewer relapses in the autumn. (https://bmcneurol.biomedcentral.com/articles/10.1186/s12883-015-0394-1)

MS relapse is directly related to Vitamin D status: and Vitamin D status is highest not in the summer, when you might expect, but in the autumn independent of dietary choices. (Maxwell, J. D. (1994). Seasonal variation in vitamin D. Proceedings of the Nutrition Society, 53(03), 533–543. doi:10.1079/pns19940063). This implies it's not just sunlight exposure that causes one's body to produce Vitamin D, but actual photoresponses and/or shifts in median temperature, or something else. So whether or not you are chronically ill or disabled, there is a good chance your Vitamin D is shifting with the seasons regardless.

[Maybe -- still trying to find an answer to this. Not a lot of people find sedentary populations worth bothering with. Shocking!]

[Edit 2: Finally!

https://onlinelibrary.wiley.com/doi/abs/10.1046/j.1440-1754.2003.00211.x
Vitamin D status of chronically ill or disabled children in Victoria

 

OK so going into December, I'm going to start upping lactoferrin (which increases monocyte and NKC activity), up my Vitamin D intake, and see how it goes. Wish me luck!

 

I am learning a lot this cool day.

 

I'm still a little concerned about the rooster thingee.