Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

Arnie Pye · Apr 26, 2020

I'm posting this because it does mention "Chronic Fatigue Syndrome" and "CFS", however it is not the focus of the paper. I thought it might be of interest to someone.

The authors are Anthony Samsel, who I've never heard of, and Stephanie Seneff who I have heard of and have read some of her papers. What research of hers I've read and understood I found to be very interesting.

Link : https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4392553/

Manganese (Mn) is an often overlooked but important nutrient, required in small amounts for multiple essential functions in the body. A recent study on cows fed genetically modified Roundup®-Ready feed revealed a severe depletion of serum Mn. Glyphosate, the active ingredient in Roundup®, has also been shown to severely deplete Mn levels in plants. Here, we investigate the impact of Mn on physiology, and its association with gut dysbiosis as well as neuropathologies such as autism, Alzheimer's disease (AD), depression, anxiety syndrome, Parkinson's disease (PD), and prion diseases. Glutamate overexpression in the brain in association with autism, AD, and other neurological diseases can be explained by Mn deficiency. Mn superoxide dismutase protects mitochondria from oxidative damage, and mitochondrial dysfunction is a key feature of autism and Alzheimer’s. Chondroitin sulfate synthesis depends on Mn, and its deficiency leads to osteoporosis and osteomalacia. Lactobacillus, depleted in autism, depend critically on Mn for antioxidant protection. Lactobacillus probiotics can treat anxiety, which is a comorbidity of autism and chronic fatigue syndrome. Reduced gut Lactobacillus leads to overgrowth of the pathogen, Salmonella, which is resistant to glyphosate toxicity, and Mn plays a role here as well. Sperm motility depends on Mn, and this may partially explain increased rates of infertility and birth defects. We further reason that, under conditions of adequate Mn in the diet, glyphosate, through its disruption of bile acid homeostasis, ironically promotes toxic accumulation of Mn in the brainstem, leading to conditions such as PD and prion diseases.
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wastwater · Apr 28, 2020

AMMONIA, GLUTAMATE, AND NEUROTOXICITY
One of the topics included

https://en.m.wikipedia.org/wiki/Glutamine_synthetase

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Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

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Glyphosate, pathways to modern diseases III: Manganese, neurological diseases, and associated pathologies

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