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Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity

Discussion in 'Other Health News and Research' started by Skycloud, Mar 7, 2018.

  1. Skycloud

    Skycloud Senior Member (Voting Rights)

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    Fructan, Rather Than Gluten, Induces Symptoms in Patients With Self-Reported Non-Celiac Gluten Sensitivity

    Gry I. Skodje et al

    Gastroentorology February 2018Volume 154, Issue 3, Pages 529–539.e2

    http://www.gastrojournal.org/article/S0016-5085(17)36302-3/fulltext

    [​IMG]
     
  2. Skycloud

    Skycloud Senior Member (Voting Rights)

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    Was alerted to this by Jen Brea tweet. My excuses for not trying fodmap, or at least fructan free, diet are dwindling. Would appreciate feedback on the paper
     
    MEMarge, Squeezy, Webdog and 3 others like this.
  3. hixxy

    hixxy Senior Member (Voting Rights)

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    Wouldn't people with supposed non-celiac gluten sensitivity still be symptomatic after avoiding gluten if it was fructans? There are a lot of other foods containing fructans that these people don't necessarily avoid.
     
    MEMarge, Skycloud and Arnie Pye like this.
  4. alicec

    alicec Senior Member (Voting Rights)

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    There is a related thread discussing a report on this study, rather than the actual study.

    I discussed what fructans actually are in that thread that noted that

    The original paper also misses the point.

    In any case, the study itself is not terribly impressive. In the summary they state

    In the results section, they go on to say,

    That's pretty dishonest in my book since many people only read the summary to get the gist of the study. The authors are deliberately trying to make their results look better than they actually are (not that the uncorrected results are outstanding either) because they are so marginal.

    The best they can scrape up is a borderline difference between fructan and gluten response. Note there is no difference between fructan and placebo response so really does this mean anything at all? If it does mean anything, they are saying that, for the overall group, there was a slightly increased response to fructans.

    They go on to look at individual response within the group and report

    The group size was 59, so about 1/4 participants had the highest response to placebo, just slightly more had the highest response to fructans and about 1/5 had the highest response to gluten.

    Not really anything to get terribly excited about and we are still none the wiser about the cause of non-coeliac gluten sensitivity.
     
    Valentijn, aaron_c, MeSci and 11 others like this.
  5. Skycloud

    Skycloud Senior Member (Voting Rights)

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    Thank you @alicec - a big help (so foggy!)
     
    MEMarge likes this.

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