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Failed PACE trial grant submissions

Discussion in 'PsychoSocial ME/CFS Research' started by daftasabrush, Jul 20, 2019.

  1. daftasabrush

    daftasabrush Senior Member (Voting Rights)

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    Before the approval of the PACE trial there were several similar failed submissions to the MRC - only when they added "Specialist" Medical Care and I think the involvement of Action for ME was the trial approved.

    Can someone point me to the rejected / failed trial applications?

    I *think* I remember one being submitted by White and Wessely, the finally approved one had Wessely's name removed I think.
     
  2. DokaGirl

    DokaGirl Senior Member (Voting Rights)

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    Interesting....
     
    MEMarge likes this.
  3. Dolphin

    Dolphin Senior Member (Voting Rights)

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    There is this document which I believe went on to be part of the successful bid. I think it may mention changes to the previous rejected/failed application.
     

    Attached Files:

  4. daftasabrush

    daftasabrush Senior Member (Voting Rights)

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    That's helpful thanks @Dolphin

    6.1 A similar application of a much smaller two arm trial (FATIMA; Grant number G9825745) was submitted in full to the MRC in 1999, rated Alpha B, but not funded. The outline proposal of this study (G010039) was approved for a full proposal in October 2001. The major innovations in this application include close collaboration with Action for ME, two new arms (APT and UMC), a much larger number of subjects and centres, and the involvement of a clinical trial unit. 6.2 We submitted a similar trial to the Department of Social Security (now Work and Pensions) in 2000, and agreement in principle to fund was given, although final funding was not forth-coming. ​

    I wondered if there was more in the MRC's secret files.
     
    MEMarge, Daisymay, EzzieD and 6 others like this.

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