Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort, 2023

[Sly Saint]

Abstract
Purpose
In this study, we explore the relationship between social jetlag (SJL), a parameter of circadian misalignment, and gut microbial composition, diet and cardiometabolic health in the ZOE PREDICT 1 cohort (NCT03479866).

Methods
We assessed demographic, diet, cardiometabolic, stool metagenomics and postprandial metabolic measures (n = 1002). We used self-reported habitual sleep (n = 934) to calculate SJL (difference in mid-sleep time point of ≥ 1.5 h on week versus weekend days). We tested group differences (SJL vs no-SJL) in cardiometabolic markers and diet (ANCOVA) adjusting for sex, age, BMI, ethnicity, and socio-economic status. We performed comparisons of gut microbial composition using machine learning and association analyses on the species level genome bins present in at least 20% of the samples.

Results
The SJL group (16%, n = 145) had a greater proportion of males (39% vs 25%), shorter sleepers (average sleep < 7 h; 5% vs 3%), and were younger (38.4 ± 11.3y vs 46.8 ± 11.7y) compared to the no-SJL group. SJL was associated with a higher relative abundance of 9 gut bacteria and lower abundance of 8 gut bacteria (q < 0.2 and absolute Cohen’s effect size > 0.2), in part mediated by diet. SJL was associated with unfavourable diet quality (less healthful Plant-based Diet Index), higher intakes of potatoes and sugar-sweetened beverages, and lower intakes of fruits, and nuts, and slightly higher markers of inflammation (GlycA and IL-6) compared with no-SJL (P < 0.05 adjusted for covariates); rendered non-significant after multiple testing adjustments.

Conclusions
Novel associations between SJL and a more disadvantageous gut microbiome in a cohort of predominantly adequate sleepers highlight the potential implications of SJL for health.

Exploring the relationship between social jetlag with gut microbial composition, diet and cardiometabolic health, in the ZOE PREDICT 1 cohort | SpringerLink

 

[Sly Saint]

Irregular sleep patterns linked to harmful gut bacteria, study suggests

Irregular sleep patterns may be linked to harmful bacteria in your gut, new research suggests.

The study is the first to find multiple associations between social jet lag – the shift in internal body clock when sleeping patterns change between workdays and free days – and diet quality, diet habits, inflammation and gut microbiome (bacteria) composition.

According to the findings, even a 90-minute difference in the midpoint of sleep – half-way between sleep time and wake-up time – can encourage microbiome that has negative associations with health.

Previous research has suggested that working shifts disrupts the body clock and can increase risk of weight gain, heart problems and diabetes.

However, according to researchers from King’s College London there is less awareness that the body’s biological rhythms can be affected by smaller inconsistencies in sleeping patterns.

This is due to people working regular hours waking early with an alarm clock on workdays compared to waking naturally on non-workdays.

Senior author Dr Wendy Hall from King’s College London, said: “We know that major disruptions in sleep, such as shift work, can have a profound impact on your health.

“This is the first study to show that even small differences in sleep timings across the week seems to be linked to differences in gut bacterial species.

“Some of these associations were linked to dietary differences but our data also indicates that other, as yet unknown, factors may be involved.

“We need intervention trials to find out whether improving sleep time consistency can lead to beneficial changes in the gut microbiome and related health outcomes.”

Irregular sleep patterns linked to harmful gut bacteria, study suggests (msn.com)

 

[rvallee]

“We need intervention trials to find out whether improving sleep time consistency can lead to beneficial changes in the gut microbiome and related health outcomes.”

It's really demoralizing seeing them aim literally at the ground, so low it's basically not aiming, and somehow missing every single time while calling bull's eye.

You are not going to optimize everyone's sleep. The premise is ridiculous to the point of being childish, like when a child imagines all the laws they'd pass in their nation if they made the rules like a king who can make everyone follow them. Might as well go with wishes having wings while we're there.

Research. The. Damn. Microbiome. Make it big. It's massively important, this nickel-and-diming approach is just worthless and expensive waste.