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Epstein-Barr Vaccination could reduce risks of B-cell lymphoma, study suggests

Discussion in 'Other health news and research' started by Milo, Apr 23, 2019.

  1. Milo

    Milo Senior Member (Voting Rights)


    Chronic B-cell activation — which can happen because of infectious mononucleosis, commonly caused by the Epstein-Barr virus (EBV) — triggers an excessive proliferation of certain B cells, which can evolve into a B-cell lymphoma. Although such chronic activation alone is not sufficient to drive cancer onset, vaccinating against EBV may work to lower the risk of getting a B-cell lymphoma, researchers say.

    The study, “Chronic CD30-signaling in B cells results in lymphomagenesis by driving the expansion of plasmablasts and B1 cells,” was published in the journal Blood.

    People who have been infected with Epstein-Barr virus have a higher risk for certain kinds of B-cell lymphomas, such as Burkitt’s lymphoma and Hodgkin’s lymphoma. Moreover, the virus is also a risk factor for several autoimmune diseases and is implicated in chronic fatigue syndrome. The underlying causes of this are still unclear.

    Infection with EBV is the most common cause of infectious mononucleosis (also known as “mono” or “kissing disease”), an acute illness characterized by fever, extreme fatigue, swollen lymph nodes in the neck and armpits, and a sore throat, along with a large expansion of specific immune cells (CD8+ T cells) trying to fight the virus.

    After entering the body, EBV establishes an initial infection at the lymphoid tissues of the throat. The virus then becomes inactive, although it may reactivate in some people.

    EBV-infected cells are normally eliminated by the immune system, but in those with a weakened immune system (e.g. after a transplant or because of AIDS), the infection may spread and drive the development of cancer.

    Infections with EBV typically result in large numbers of B cells carrying CD30, a surface receptor abundant in several lymphomas. However, the role of CD30-signaling and its contribution to the development of lymphomas is still poorly understood.

    Ursula Zimber-Strobl, PhD, and her team at Helmholtz Zentrum München, in Germany, have been studying the biology of EBV as a tool to understand the development and function of the immune system, particularly B cells.

    In this study, which was supported by German Cancer Aid, she and her team worked to decipher the link between CD30 and these events, in particular the development of B-cell lymphomas.

    Before their study, it was not clear “whether the production of CD30 on the surface of lymphoma cells is merely a result of the cancer or whether it causally contributes to it,” Zimber-Strobl said in a press release.

    Bearing this in mind, the team used mouse models to study two questions: how CD30 is expressed across different B-cell types and whether persistent activation of CD30 in B cells — which can result from prolonged stress on the immune system, for example, at the onset of infectious mononucleosis — can trigger the development of lymphoma

    (Continues at the link above)

    Fascinating article, and it makes one wonder, perhaps these researchers could be reached out to, so they could have a cohort of EBV-triggered ME patients to see what they could find. Cancer researchers benefit from large amounts of funding.
  2. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    As far as I know, there is no EBV vaccine so this remains hypothetical...
    MEMarge, NelliePledge and Trish like this.
  3. Milo

    Milo Senior Member (Voting Rights)

    MEMarge likes this.
  4. BruceInOz

    BruceInOz Senior Member (Voting Rights)

    Must be hard to tease this out properly given that 95% of adults have been infected with EBV.
    Snow Leopard and oldtimer like this.
  5. Milo

    Milo Senior Member (Voting Rights)

    In my case I got EBV following saliva exposure from a cancer patient whose cancer is listed as one of the cancer caused by EBV. It makes one think twice. Could it be a different or more agressive strain?

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