Energy metabolism disturbance in migraine: From a mitochondrial point of view, 2023, Yicheng Wang

Conclusion
In the past few years, we have made great progress in understanding the mechanism of energy metabolism in migraine. KCL-induced CSD and nitroglycerin-induced cerebral vasodilation are commonly used migraine models, which can cause disorders of energy metabolism and lead to oxidative phosphorylation and TCA dysfunction. The dysfunction of oxidative phosphorylation is mainly related to calcium ions, mPTP, mitochondrial membrane potential, CYPD, OSCP, TSPO, and the Bcl-2 family.

Oxidative phosphorylation inhibitors are also the focus of attention. In some studies, oxidative phosphorylation inhibitors can be used to specifically inhibit complex I, complex II, complex III, and complex IV, to observe the corresponding affected proteins.

The relationship between ROS and energy metabolism is also very close. Too much ROS will lead to oxidative stress, which will promote the opening of mPTP, and then affect the expression of pro-apoptotic and anti-apoptotic proteins of the Bcl-2 family. ROS and CGRP, TRPA1, and TRPV1 can interact to cause migraine.

https://www.frontiersin.org/journals/physiology/articles/10.3389/fphys.2023.1133528/full