Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a... 2025 Smakowski, Rosmalen et al

[Andy]

Empirical assessment of functional somatic disorder (FSD): frequency, applicability, and diagnostic refinement in a population-based sample

Abstract

Background
Persistent and troublesome physical symptoms are common and can, regardless of their cause, greatly impair patients’ quality of life. Reflecting complex brain-body interactions, they are observed across all healthcare specialties, commonly overlap across them, and receive inconsistent diagnoses. In response, the international research network EURONET-SOMA has proposed a diagnostic classification for persistent and troublesome symptoms entitled “functional somatic disorder (FSD)”. Focusing on symptom patterns across organ systems, the FSD approach aims to enhance diagnosis, treatment, and healthcare access for patients. However, further research is needed to validate its effectiveness and clinical utility. This study assessed the frequency and applicability of the FSD proposal within a population-based sample.

Methods
FSD diagnostic criteria were cross-sectionally operationalised within the multi-disciplinary prospective cohort study Lifelines, conducted in the Dutch population. Kruskal–Wallis and chi-square tests with effect size estimates were used to investigate differences in the diagnostic subgroups regarding chronic diseases, functional comorbidities and psycho-behavioural features. Binary logistic regression with elastic net penalisation was used to investigate sociodemographic, psycho-behavioural and clinical factors associated with FSD.

Results
Of the study population (N = 88,925), 58% met the diagnostic criteria for FSD. Of those meeting FSD, 31% reported a single distressing symptom, 18% had several symptoms attributable to one organ system and 52% reported multiple symptoms from various organ systems. Moderate differences between these subgroups were found for health status, neuroticism, long-term life difficulties and healthcare utilisation. Elastic net regression showed comorbid chronic musculoskeletal (OR 1.8), gastrointestinal disease (OR 1.4), neurological disease (OR 1.2), and female sex (OR 1.2) predicted FSD. Concurrent anxiety (OR 1.6), healthcare visits (OR 1.3) and long-term difficulties (OR 1.2) were associated with the presence of FSD.

Conclusions
This study supports refining the FSD criteria to avoid over-inclusiveness. Current symptom severity and frequency thresholds need adjustment to better identify those needing treatment. The distinction between single and multiple symptom categories is important, and optional specifiers like comorbid chronic diagnoses and psychological factors seem valuable for predicting FSD. Despite warranting further research, the FSD classification is promising for diagnosing persistent and troublesome symptoms across medical specialties.

Open access

 

[Utsikt]

They are essentially asking: how can we best identify and classify the patients that we believe have symptoms caused by psychosocial factors.

Not: how can we determine if a patient has symptoms caused by psychosocial factors.

It’s all make believe and fairytales.

 

[rvallee]

Despite warranting further research, the FSD classification is promising for diagnosing persistent and troublesome symptoms across medical specialties.

Well, all I need to complete my table-top cold fusion device capable of producing 1MW of clean energy using only a table spoon of water is to complete the device. So in that sense, we are equally close and far apart from our goals. Just like all Theranos needed to become a successful business selling complex diagnostic devices was to actually build functioning devices.

The main difference with them is that Theranos operated in a context in which those who paid for its development demanded results, whereas this psychosocial nonsense just goes on indefinitely. It's just as fraudulent, but while there is a financial fraud police, there isn't one for fraudulent health care.

I genuinely have no idea what they're trying to accomplish. This way of doing things has absolutely zero potential to produce anything useful, it's nothing but a rhetorical device to confirm hypothetical models without making sense of reality. They have far more in common with the proponents of scientific racism than anything having to do with medicine, health or health care.

 

[Snow Leopard]

58% of the general population, sounds like it should be abandoned altogether due to lack of specificity.

 

[Utsikt]

58% of the general population, sounds like it should be abandoned altogether due to lack of specificity.

And it’s not like this couldn’t have been predicted when they decided to make the criteria so broad. But hey, I guess they needed a study to fund their salary for a while.