Andy
Retired committee member
Many patients infected with SARS-CoV-2 report persistent symptoms that may impair their quality of life for months, even after a mild episode of coronavirus disease 2019 (COVID-19), a situation often referred to as ‘long COVID’. Figures vary between studies but the proportion of patients affected may be around 20% at 6 months post-infection and 10% at 12 months [1], making this a public health issue and a priority for medical research. Although the potential role of psychological mechanisms in long COVID has long been hypothesized, it has been relatively overlooked so far compared to other potential mechanisms [2]. In line with the principles of psychosomatic medicine, we argue that this hypothesis is worth considering to understand long COVID and to relieve patients who suffer from it.
First, there is already substantial evidence suggesting a role for psychological mechanisms in long COVID. For instance, it is now well-established that psychological distress is not only a symptom but also a risk factor of long COVID. Early in the pandemic, a history of psychiatric disorders was shown to be an independent predictor of ‘Post-acute Sequelae of COVID-19’ (PASC) [3,4]. Recently, psychological distress measured at the beginning of the pandemic was associated with the risk of persistent symptoms in individuals later infected with SARS-CoV-2, with a dose-response relationship [5]. It is noteworthy that this association was stronger than those observed for other risk factors of long COVID. However, it remains unknown whether this association is only observed in those infected with SARS-CoV-2. For instance, pandemic-related anxiety in the general population has been associated with physical symptoms that may mimic those of long COVID [6]. In contrast to psychological distress, higher levels of personal resilience have been associated with lower severity of PASC [7]. Beyond psychological distress, a recent observational study linked specific beliefs about COVID-19 – such as one's estimated symptom severity if infected and perception of the body's ability to fight diseases – with the experience of symptoms weeks afterwards [8]. Likewise, a cohort study found that symptom expectations associated with COVID-19 and self-reported history of COVID-19 better predicted the worsening of somatic symptom burden during the COVID-19 pandemic than serology test results [9]. Although these findings do not mean than other mechanisms could not be involved, they suggest that at least some persistent symptoms in some patients may be influenced by psychological factors.
Open access, https://www.sciencedirect.com/science/article/pii/S0022399922004202
First, there is already substantial evidence suggesting a role for psychological mechanisms in long COVID. For instance, it is now well-established that psychological distress is not only a symptom but also a risk factor of long COVID. Early in the pandemic, a history of psychiatric disorders was shown to be an independent predictor of ‘Post-acute Sequelae of COVID-19’ (PASC) [3,4]. Recently, psychological distress measured at the beginning of the pandemic was associated with the risk of persistent symptoms in individuals later infected with SARS-CoV-2, with a dose-response relationship [5]. It is noteworthy that this association was stronger than those observed for other risk factors of long COVID. However, it remains unknown whether this association is only observed in those infected with SARS-CoV-2. For instance, pandemic-related anxiety in the general population has been associated with physical symptoms that may mimic those of long COVID [6]. In contrast to psychological distress, higher levels of personal resilience have been associated with lower severity of PASC [7]. Beyond psychological distress, a recent observational study linked specific beliefs about COVID-19 – such as one's estimated symptom severity if infected and perception of the body's ability to fight diseases – with the experience of symptoms weeks afterwards [8]. Likewise, a cohort study found that symptom expectations associated with COVID-19 and self-reported history of COVID-19 better predicted the worsening of somatic symptom burden during the COVID-19 pandemic than serology test results [9]. Although these findings do not mean than other mechanisms could not be involved, they suggest that at least some persistent symptoms in some patients may be influenced by psychological factors.
Open access, https://www.sciencedirect.com/science/article/pii/S0022399922004202