This edition of WORK: A Journal of Prevention, Assessment and Rehabilitation features research, recommendations and lived/personal experience with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS), a chronic, debilitating disease that affects 1 to 2.5 million Americans. Personally, this project has been an exciting opportunity and a great learning experience. My role as the special edition editor merges my background as an occupational therapy practitioner and my experience as caregiver of a child with severe ME/CFS. In my wildest dreams, I would never have imagined this path. But as I have come to realize, paths aren’t always choices, they are callings and we go where we are needed. I am extremely grateful to Karen Jacobs, Editor-in-Chief, for this opportunity.