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Ebola virus disrupts the inner blood-retinal barrier by induction of vascular endothelial growth factor in pericytes 2023 Gao et al

Discussion in 'Other health news and research' started by Andy, Jan 19, 2023.

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  1. Andy

    Andy Committee Member

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    21,912
    Location:
    Hampshire, UK
    Abstract

    Ebola virus (EBOV) causes severe hemorrhagic fever in humans with high mortality. In Ebola virus disease (EVD) survivors, EBOV persistence in the eyes may break through the inner blood–retinal barrier (iBRB), leading to ocular complications and EVD recurrence. However, the mechanism by which EBOV affects the iBRB remains unclear. Here, we used the in vitro iBRB model to simulate EBOV in retinal tissue and found that Ebola virus-like particles (EBO-VLPs) could disrupt the iBRB. Cytokine screening revealed that EBO-VLPs stimulate pericytes to secrete vascular endothelial growth factor (VEGF) to cause iBRB breakdown. VEGF downregulates claudin-1 to disrupt the iBRB. Ebola glycoprotein is crucial for VEGF stimulation and iBRB breakdown. Furthermore, EBO-VLPs caused iBRB breakdown by stimulating VEGF in rats. This study provides a mechanistic insight into that EBOV disrupts the iBRB, which will assist in developing new strategies to treat EBOV persistence in EVD survivors.

    Author summary
    Ebola virus (EBOV) persistence in eyes has been frequently reported and has become an enormous international public health challenge. EBOV persistence in the eyes may break through the inner blood–retinal–barrier (iBRB), leading to ocular complications and EBOV recurrence. However, the mechanism by which EBOV affects the iBRB remains unclear. Here, we found that Ebola virus-like particles stimulate retinal pericytes to secrete vascular endothelial growth factor (VEGF) to cause iBRB breakdown. VEGF causes iBRB breakdown by disrupting the tight junction protein claudin-1. Ebola glycoprotein plays a key role in VEGF stimulation and iBRB breakdown. Our study provides a mechanistic insight into that EBOV disrupts the iBRB, which will assist in developing new strategies to treat EBOV persistence in EBOV survivors.

    Open access, https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1011077
     
    Andy, Jan 19, 2023
    #1
    SNT Gatchaman, alktipping, Peter Trewhitt and 1 other person like this.
  2. Hutan

    Hutan Moderator Staff Member

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    26,844
    Location:
    Aotearoa New Zealand
    Post-Ebola syndrome is similar (perhaps the same? as) ME/CFS. Ebola persists in immune-privileged sites and cannot be identified from blood tests.


    An anti-VEGF medication was found to reduce barrier dysfunction (although presumably, if you don't eliminate the Ebola virus, the dysfunction would continue).

    They give numerous examples of viruses affecting the integrity of vascular endothelium by various means.
     
    Hutan, Jan 19, 2023
    #2
    NelliePledge, Ash, Art Vandelay and 2 others like this.

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