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Drug decreases gut leakiness associated with ulcerative colitis

Discussion in 'Health News and Research unrelated to ME/CFS' started by Andy, Jan 3, 2020.

  1. Andy

    Andy Committee Member & Outreach

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    https://medicalxpress.com/news/2019-12-drug-decreases-gut-leakiness-ulcerative.html
     
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  2. Solstice

    Solstice Senior Member (Voting Rights)

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    M.E. is to my best knowledge often associated with leaky gut. Which is why there's such an emphasis on the gut. But much more promising and measured jak-inhibitors are already in the final stages of testing(upaciditinib, filgotinib). And if I recall correctly, trials on m.e. are already underway or at least funded for those drugs.
     
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  3. Andy

    Andy Committee Member & Outreach

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    The study talked about in the article above.

    The JAK-Inhibitor Tofacitinib Rescues Human Intestinal Epithelial Cells and Colonoids from Cytokine-Induced Barrier Dysfunction
    Paywall, https://academic.oup.com/ibdjournal/advance-article-abstract/doi/10.1093/ibd/izz266/5637473
    Sci hub, https://sci-hub.se/10.1093/ibd/izz266
     
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  4. MarcNotMark

    MarcNotMark Senior Member (Voting Rights)

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  5. Andy

    Andy Committee Member & Outreach

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    Interestingly the drug, tofacitinib, is talked about in this paper.

    JAK/STAT Blockade Alters Synovial Bioenergetics, Mitochondrial Function, and Proinflammatory Mediators in Rheumatoid Arthritis
    Open access, https://onlinelibrary.wiley.com/doi/full/10.1002/art.40569
     
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  6. butter.

    butter. Senior Member (Voting Rights)

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    do you have a link for that information? could not find anything! ty!
     

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