Gene mutation IDO2 Every ME/CFS patient has this mutation. Biochemists and Geneticists say IDO2 is not necessary, it doesn't have a function. Clearly not true as every patient has this mutation. We have hypothesis: No details yet but called 'Metabolic trap'. We are trying to prove hypothesis wrong which is the right way to go. One compound that is made in the gut and it appears that the bacteria is missing in the patients and that product is used to protect the brain.