Moderator note: This post has been copied and subsequent posts moved from this thread: Concerns about craniocervical instability surgery in ME/CFS _________________________________ Chronic Fatigue Syndrome is a such a vague diagnosis that it can cover many things since fatigue is such a common symptom but ME is a specific diagnosis. It is only when it is used as a synonym of CFS that there is confusion. The effects of exertion we experience are not seen in any other disease. ME is a disease of energy metabolism. The Workwell institute work has shown that our aerobic system does not work properly and we rely heavily on anaerobic respiration for our energy. This is a useful explanation for our symptoms and matches what people with ME have claimed to experience for years. What I cannot see is why fixing a mechanical problem could relieve the post exertional problems we experience. If it is the sole cause of someone's symptoms then where is the energy problem of ME? If someone has true PEM then this must remain after the operation so they could still end up bedridden. In fact the relief of some symptoms could lead someone to do too much and we have seen how many people end up worse than they started when an improvement means they do too much.