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Diagnosis of major depressive disorder based on changes in multiple plasma neurotransmitters: a targeted metabolomics study

Discussion in 'Health News and Research unrelated to ME/CFS' started by Sid, Sep 27, 2018.

  1. Sid

    Sid Senior Member (Voting Rights)

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    Small sample size but strengths of the study include using medication-free first-episode major depression and an illness control group (bipolar disorder).


    Full text at: https://www.nature.com/articles/s41398-018-0183-x
     
    Pechius, Hutan, hixxy and 6 others like this.
  2. strategist

    strategist Senior Member (Voting Rights)

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    The two biggest changes (both increases) were tyramine and dopamine levels.

    Tyramine was 19.26±4.30 in patients and 1.98±0.33 in controls. Dopamine was 1.01±0.16 in patients and 0.28±0.04 in controls. Many of the other neurotransmitters had smaller changes.

    How does this relate to monoamine oxidase inhibitors? Wouldn't they increase tyramine further?
     
  3. Sid

    Sid Senior Member (Voting Rights)

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    This study measured plasma metabolites. What's going on in the brain is anyone's guess until we see some CSF data.
     
    WillowJ, Hutan, hixxy and 6 others like this.
  4. Hutan

    Hutan Moderator Staff Member

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    From the abstract, it looks like quite a nice study and pretty important: a potential biomarker holding up well when checked on a testing set.

    It leaves me wondering why no one did this study before. Perhaps it's indicative of biomedicine becoming more important in what have been labelled psychiatric conditions?
     
  5. Sid

    Sid Senior Member (Voting Rights)

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    There have been some previous metabolomic studies of MDD and other conditions labelled psychiatric but you know how it goes, everyone measures different things. There are a lot of metabolites.
     

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