DecodeME blog: X marks the spot where ME/CFS biology can be discovered

[Mij]

Does gene regulation switch on and off during the onset of delayed PEM? I'm personally no longer stuck on an ME diagnosis or who fits the criteria, onset, mild/moderate/severe et

 

[jnmaciuch]

Yes, these specific parts:
View attachment 27588

Edit: Seems to pretty much be all over the brain though.

That part definitely stuck out to me. The fact that the set of genes is enriched across all those regions in the brain cumulatively suggests that (if it is the neurological function of these genes that matters) it’s something about general functioning of a neuron-type cell, rather than a specific neural function or part of the brain like the hypothalamus, that might predispose someone to ME/CFS.

Unfortunately these results don’t give any indication of where that relevant function might be. It’s also just as likely that this signature is relevant in the peripheral nervous system rather than the central nervous system.