Daxor Blood Volume Measurement System

[forestglip]

Thread for the blood volume measurement system made by Daxor.

"Daxor Corporation (NASDAQ: DXR) is tackling healthcare’s “multi-billion-dollar silent crisis”, the inability to precisely measure blood volume. This often results in suboptimal care, prolonged hospital stays, and increased readmissions for many high-cost medical conditions like heart failure and those requiring ICU care.

With 50 years of experience and innovation, Daxor’s patented, FDA-cleared Blood Volume Analysis (BVA) diagnostic offers unmatched, real-time, precise data via its rapid, hand-held lab-based system. This empowers clinicians to make individualized treatment decisions that significantly improve patient outcomes and deliver substantial efficiencies in value-based healthcare.

Daxor is ISO certified and operates a U.S.-based, 20,000-square-foot state-of-the-art manufacturing facility, positioning the company for accelerated market."

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Press Release: Daxor Corporation Receives FDA Clearance for New Rapid, Lightweight, Blood Volume Analysis System

"Oak Ridge, TN — August 7, 2025 – Daxor Corporation (NASDAQ: DXR), the global leader in blood volume measurement technology, today announces FDA 510(k) clearance (K251087) for its patent-pending next-generation rapid, compact, hand-held, lab-based Blood Volume Analyzer (BVA).

The new Daxor BVA™ device quantifies a patient’s blood volume against patient-specific norms, enabling precise fluid management across a broad spectrum of clinical conditions affecting millions of patients each year."

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Requested to be posted by @ahimsa

 

[ahimsa]

I hope folks who understand the science behind this type of testing can comment on whether it looks like a promising test for research or not.

 

[Jonathan Edwards]

It looks like a test that has been going for 50 years and they have just produced a lightweight handset analyser. It seems to use a radioactive label, which is a pity but probably fairly harmless.

 

[Utsikt]

How does this work? You take a basline blood draw, inject a tracer, take multiple new blood draws at set intervals, and use the change in the ratio of tracer to estimate blood volume?

 

[Jonathan Edwards]

How does this work? You take a basline blood draw, inject a tracer, take multiple new blood draws at set intervals, and use the change in the ratio of tracer to estimate blood volume?

You probably don't need a baseline blood draw if you are measuring a radioactive tracer but it might be good practice. You inject a tracer and expect blood to mix well enough by say 10 minutes to estimate blood volume as the volume of distribution of your tracer.

With concentration of tracer Cb in bolus injected of volume B and concentration Cd in 10 minute sample allows calculation of blood volume V as: (I hope)

Cd x V = Cb x B
or
V = B x Cb/Cd

But there is a slow leakage of tracer from blood to tissue fluid and lymph and that leakage has already lowered Cd by 10 minutes. To compensate for that you take further samples at regular intervals and watch the rate of further loss to tissue fluid. You then extrapolate back to time of injection to get a value for a notional state of perfect mixing in blood but no leakage. Things are a bit more complicated in reality but having done studies a bit like this I have been impressed by how well behaved vascular space shifts tend to be.