Cyclophosphamide drug questions?

Wonder if someone could help clarify things please.

Is the CycloME Part A trial being published any time soon?

Does the results from rituximab lower expectations for the results for cyclo?

Also, what is the theory behind cyclo working in ME?

Thanks

 

It is due to be published early 2018.

I can't speak about the expectations, but clearly the trial investigators believe it has an effect as they extended the original follow up period and then they proceeded with part B.

I spoke with one of the investigators at iime and she indicated that it works, however I don't know if this means a whole lot, given they probably believed rituximab worked too.

 

Thanks for reply

I'm just concerned that Cyclophosphamide treatment rationale is the same as rituximab. Due to the negative results from rituximab, whether this means cyclophosphamide probability of working is lowered

 

It seems to have a completely different mechanism:

https://www.medicinenet.com/cyclophosphamide/article.htm

 

So would we be looking for what is considered a side effect for cancer patients?

It is also something that suppresses B cells, which was my assumption about why they picked it. This possibly is bad news. Though there was something reassuring about cyclo looking more promising in with the news IIRC

 

I think the background is similar, in that cancer patients with ME seemed to recover.
However it does have a much broader effect than rtx, so if the problem is in the immune system, just because rtx failed, wouldn't necessarily suggest that cyclo will fail too.

 

Hello,

Anybody have any info on the status of the publication of the Norwegian cyclo study?

It’s no longer early 2018. Maybe article needed major revision?

Thanks.

 

Its not?

https://www.youtube.com/watch?v=LAlaVnDyzIA

 

https://helse-bergen.no/seksjon-eng...atment and Medical Physics/Sider/CycloME.aspx

 

Thanks—I had kept hearing early 2018.