Shiqiru
Established Member
Consumption-Driven Feedback: A Unified Immunoregulatory Theory of Antibody Production Dynamics
Abstract
The "Consumption-Driven Feedback" (CDF) theory seeks to explain pathogenic autoantibody origins and general immune regulation. CDF posits the immune system dynamically regulates B-cell clonal expansion and antibody production by sensing circulating antibody consumption alone or with antigen stimulation, providing a unified dynamic framework for diverse complex immune phenomena. CDF is based on solid clinical observations, e.g., rapid antibody rebound after plasmapheresis. Its evolutionary rationale is twofold: combating exponential pathogen threats (via consumption signals to drive antibody expansion) and maintaining baseline protection. CDF reinterprets multiple immunological phenomena, including IgM's early role. Critically, it sees autoimmune diseases not as defects but as "immune costs" from normal CDF under specific conditions. Acute infections especially in antigen decay can "ignite" autoimmune seeds by enabling self-reactive clones to gain advantage. Once autoantibodies and autoantigens form sustained consumption, CDF triggers a vicious cycle, sustaining chronic autoimmune pathology. Meanwhile, each infection reshapes the body's "autoimmune kindling pool," explaining autoimmunity origin and heterogeneity in Long COVID. CDF also proposes a "dual-cycle coordinated regulation model," with hourly local response and circadian global calibration. It explores immune response spatial dynamics and explains "post-exertional malaise" (PEM) in ME/CFS patients via CDF. To validate CDF, this paper presents an end-to-end longitudinal tracking strategy, quantifying antibody clonal dynamics and pulmonary oxygen reserve capacity (ORC) changes tied to pathology. Preliminary cases offer encouraging clues for its predictions. Also, interventional methods (e.g., "synchronized therapy") are proposed, and CDF's integration with existing Long COVID hypotheses is discussed.
https://open.substack.com/pub/shiqi...eedback-a-unified-cff?r=6m1emj&utm_medium=ios
Abstract
The "Consumption-Driven Feedback" (CDF) theory seeks to explain pathogenic autoantibody origins and general immune regulation. CDF posits the immune system dynamically regulates B-cell clonal expansion and antibody production by sensing circulating antibody consumption alone or with antigen stimulation, providing a unified dynamic framework for diverse complex immune phenomena. CDF is based on solid clinical observations, e.g., rapid antibody rebound after plasmapheresis. Its evolutionary rationale is twofold: combating exponential pathogen threats (via consumption signals to drive antibody expansion) and maintaining baseline protection. CDF reinterprets multiple immunological phenomena, including IgM's early role. Critically, it sees autoimmune diseases not as defects but as "immune costs" from normal CDF under specific conditions. Acute infections especially in antigen decay can "ignite" autoimmune seeds by enabling self-reactive clones to gain advantage. Once autoantibodies and autoantigens form sustained consumption, CDF triggers a vicious cycle, sustaining chronic autoimmune pathology. Meanwhile, each infection reshapes the body's "autoimmune kindling pool," explaining autoimmunity origin and heterogeneity in Long COVID. CDF also proposes a "dual-cycle coordinated regulation model," with hourly local response and circadian global calibration. It explores immune response spatial dynamics and explains "post-exertional malaise" (PEM) in ME/CFS patients via CDF. To validate CDF, this paper presents an end-to-end longitudinal tracking strategy, quantifying antibody clonal dynamics and pulmonary oxygen reserve capacity (ORC) changes tied to pathology. Preliminary cases offer encouraging clues for its predictions. Also, interventional methods (e.g., "synchronized therapy") are proposed, and CDF's integration with existing Long COVID hypotheses is discussed.
https://open.substack.com/pub/shiqi...eedback-a-unified-cff?r=6m1emj&utm_medium=ios