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Comorbidities in a Nationwide, Heterogenous Population of Veterans with Interstitial Cystitis/Bladder Pain Syndrome, 2021, Laden et al

Discussion in 'Psychosomatic research - ME/CFS and Long Covid' started by Andy, Apr 27, 2021.

  1. Andy

    Andy Committee Member

    Hampshire, UK

    To examine the prevalence of comorbid conditions in a nationwide population of men and women with IC/BPS utilizing a more heterogeneous sample than most studies to date.


    Using the Veterans Affairs Informatics and Computing Infrastructure, we identified random samples of male and female patients with and without an ICD-9/ICD-10 diagnosis of IC/BPS. Presence of comorbidities (NUAS [chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, migraines], back pain, diabetes, and smoking) and psychosocial factors (alcohol abuse, post-traumatic stress disorder, sexual trauma, and history of depression) were determined using ICD-9 and ICD-10 codes. Associations between these variables and IC/BPS status were evaluated while adjusting for the potential confounding impact of race/ethnicity, age, and gender.


    Data was analyzed from 872 IC/BPS patients (355 [41%] men, 517 [59%] women) and 558 non-IC/BPS patients (291 [52%] men, 267 [48%] women). IC/BPS patients were more likely than non-IC/BPS patients to have a greater number of comorbidities (2.72+/-1.77 vs 1.73+/-1.30, p<0.001), experience one or more NUAS (chronic fatigue syndrome, fibromyalgia, irritable bowel syndrome, and migraines) (45% [388/872] vs. 18% [101/558]; p<0.001) and had a higher prevalence of at least one psychosocial factor (61% [529/872] v. 46% [256/558]; p<0.001). Differences in the frequencies of comorbidities between patients with and without IC/BPS were more pronounced in female patients.


    These findings validate the findings of previous comorbidity studies of IC/BPS in a more diverse population.

    Paywall, https://www.goldjournal.net/article/S0090-4295(21)00343-5/fulltext
    Trish and Peter Trewhitt like this.
  2. Mithriel

    Mithriel Senior Member (Voting Rights)

    Interstitial cystitis is classed as a functional neurological disorder by Stone.

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