Chronic Phase Lipids in Sera of Several Chronic Diseases Reacting with MAB–CTX (Antibody to Ciguatoxin), 2003, Hokama et al

Hutan

Hutan

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Abstract
The membrane immunobead assay results on the acetone lipid fraction of serum from chronic fatigue syndrome (CFS) patients (60 samples) and normal individuals (with no clinical CFS or other disease symptoms) showed significant differences with 4 exceptions (4 normals showed 1:40 and 1:80 titres). This represented approximately 10.8% of the normal samples, with 3 samples at 1:20, the majority of the CFS titred 1:40 through 1:160. This represented 95.0% of the samples. The small numbers of hepatitis patients and chronic ciguatera fish poisoning patients also had titres of 1:40 to 1:80 in all of the serum samples examined. The weights of the lipids in mg/ml serum essentially are very similar, except 1 or 2 of CFS and hepatitis B showed values at the upper level. Comparison of sexes showed 65% females and 35% men with CFS, representing a ratio of approximately 2:1 (female/male).

It is concluded that certain disease conditions and environmental exposures to deleterious factors (toxin, chemicals, microorganisms) trigger the release of lipids (probably by the liver) with similar epitopes to ciguatoxin, and that they react with MAb–CTX. We designate these lipids as “chronic phase lipids” comparable to “acute phase protein” in inflammatory and traumatic diseases.

https://www.tandfonline.com/doi/full/10.1081/TXR-120026913?scroll=top&needAccess=true

Dr Yoshitsugi Hokama
Department of Pathology, John A. Burns School of Medicine, University of Hawaii, Manoa, Honolulu, Hawaii, 96822, USA
 
This is an old paper, one that I remember reading early on in my illness and that I felt might be important, although I can't find a link to the full paper now. I think it's an intriguing idea, that the body is producing toxins as a result of "certain disease conditions and environmental exposures" with "similar epitopes to ciguatoxin". There are a few discussions on the forum on the idea that ME/CFS might be similar to chronic ciguatera - they can be found by clicking on the ciguatera tab on the top left.

I would like to know if anyone has tried to replicate the study.

@strategist posted the following paragraph on this thread:
Metabolomic Evidence for Peroxisomal Dysfunction in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome, 2022, Levine,Hornig,Lipkin et al
There are earlier studies which point to fats in the circulation as markers, and possible effectors of the disease. In 2003 Yoshitsugi Hokama’s discovery, showing that a lipid in the sera of patients cross-reacted to the antibody used to detect ciguatera toxin [23] shot like a bolt of light across the sky. Later, in 2009, it was determined that the identity of the antigen was phospholipids associated with cardiolipin from the mitochondria [22]. Unfortunately, further studies did not take place. Assuming this result was correct, this leaves the question: what are these phospholipids doing at increased concentrations in the blood? A likely consequence of Che and Lipkin’s study is that there may be increased, toxic, oxidized, lipids in the blood of patients with ME, which could, in some measure, also vindicate this early study.
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