1. Guest, 'News in Brief' for the week beginning 14th September 2020 is here.
    Dismiss Notice
  2. Welcome! To read the Core Purpose and Values of our forum, click here.
    Dismiss Notice

Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function - Taiwu Wang

Discussion in 'BioMedical ME/CFS Research' started by Sly Saint, Sep 12, 2018.

Tags:
  1. Sly Saint

    Sly Saint Senior Member (Voting Rights)

    Messages:
    5,104
    Likes Received:
    42,322
    Location:
    UK
    Chronic fatigue syndrome patients have alterations in their oral microbiome composition and function
    • Taiwu Wang ,
    • Lei Yu ,
    • Cong Xu,
    • Keli Pan,
    • Minglu Mo,
    • Mingxiang Duan,
    • Yao Zhang ,
    • Hongyan Xiong
    [​IMG]
    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203503
     
  2. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    Do they know it leads to shifts in functional metabolic pathways? This is different from saying it’s associated. Could altered metabolic pathways lead to altered microbiome? Eg mitochondrial dysfunction leading to impaired immunity leading to altered microbiome, or altered response to glucose altering bacteria diet in mouth/gut leading to different microbiome composition?
     
    Last edited: Sep 12, 2018
    Lidia, Hutan, JaimeS and 9 others like this.
  3. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    [​IMG]

    Prevolella looks interesting

     
  4. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    [​IMG]

    Apart from anything re oral microbiome this seems interesting re metabolomics too

    @JaimeS do you have any thoughts? What else has this research group done?
     
    JaimeS and adambeyoncelowe like this.
  5. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    Would it be relatively easy to process oral microbiome samples compared to [poop emoticon]?
     
    JaimeS, andypants and adambeyoncelowe like this.
  6. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    So are they saying controls who had similar microbiome also had similar metabolomics? That might indicate certain bacteria are causing problems. But then the controls presumably don’t have symptoms so does it indicate that?! Perhaps the microbiome and KEGG pathway results are both red herrings?

    Referring to the bigger effect in ME gut studies (not oral)
    So cultural/regional differences in the nature of the differences but with same symptoms might infer microbiome differences are downstream of the root cause depending on diet?
     
    merylg, Esther12 and adambeyoncelowe like this.
  7. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    But We don’t think HIV is caused by microbiome issues, so this seems more indication that this is something that can happen as a consequence of altered immune function not suggesting it’s key to CFS pathogenesis?
     
    Last edited: Sep 12, 2018
    merylg, Keela Too, JaimeS and 4 others like this.
  8. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    I’d say these are subtyping factors rather than confounding factors and may contain the most important information. Eg what would this look like split pre and post 3 year duration?

    It would be great if researchers consistently subgrouped by these factors, instead of just listing the limitation (it doesn’t seem like this would take substantially more time and money and could result in important, extra publications from the same project).
     
    Last edited: Sep 12, 2018
    Esther12, andypants, Skycloud and 2 others like this.
  9. aquariusgirl

    aquariusgirl Established Member

    Messages:
    4
    Likes Received:
    8
    Merged thread

    https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0203503

    the overall microbiome composition was different (MANOVA, p < 0.01). CFS patients had a higher relative abundance of Fusobacteria compared with healthy controls. Further, the genera Leptotrichia, Prevotella, and Fusobacterium were enriched and Haemophilus, Veillonella, and Porphyromonas were depleted in CFS patients compared to healthy controls. Functional analysis from inferred metagenomes showed that bacterial genera altered in CFS patients were primarily associated with amino acid and energy metabolism.
     
    Last edited by a moderator: Sep 12, 2018
  10. lansbergen

    lansbergen Senior Member (Voting Rights)

    Messages:
    616
    Likes Received:
    2,243
    I go for a consequence of altered immune function.
     
    JaimeS, andypants, Trish and 4 others like this.
  11. hixxy

    hixxy Senior Member (Voting Rights)

    Messages:
    119
    Likes Received:
    680
    Fukuda criteria.
    I'd be surprised if it's not similar and they're not measuring the same thing so not really interchangeable.
     
  12. Jenny TipsforME

    Jenny TipsforME Senior Member (Voting Rights)

    Messages:
    400
    Likes Received:
    2,083
    I get the impression they were hoping to have results strong enough to find a biomarker. I was wondering if this was partly because it’s easier/cheaper to get oral samples than testing gut microbiome?
     
    Keela Too and JaimeS like this.
  13. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    1,248
    Likes Received:
    9,455
    Location:
    Stanford, CA
    Innnnteresting but my brain is fried from every US institution (except for u, NIH) exploding on us all at once. #MEAction is working HARD.

    So all I can say for now is... I'll look at it for the research roundup? :D
     
    Alvin, andypants, merylg and 3 others like this.
  14. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    1,248
    Likes Received:
    9,455
    Location:
    Stanford, CA
    This is going to be in the double-month research roundup which will be released today (and go out in social media tomorrow).

    I don't recognize any of the names here, though.
     
  15. JaimeS

    JaimeS Senior Member (Voting Rights)

    Messages:
    1,248
    Likes Received:
    9,455
    Location:
    Stanford, CA
    I would say it's rather chicken and egg still.
     
    merylg, Alvin and andypants like this.
  16. Michiel Tack

    Michiel Tack Senior Member (Voting Rights)

    Messages:
    1,889
    Likes Received:
    17,995
    Location:
    Belgium
    I don't think this study found something robust. They themselves highlight that differences were minor...

    It's exciting though to have a Chinese research team studying mecfs. Lets hope they will stick around!
     
    merylg, Manganus and Hutan like this.

Share This Page