Chronic fatigue & fibromyalgia symptoms [] key components of deficit schizophrenia & [] associated w/activated immune-inflammatory.., 2020, Maes et al

Andy · May 30, 2020

Full title: Chronic fatigue and fibromyalgia symptoms are key components of deficit schizophrenia and are strongly associated with activated immune-inflammatory pathways

I'd suggest that there is total conflation between chronic fatigue and 'chronic fatigue syndrome' here.

There is now evidence that schizophrenia and especially deficit schizophrenia (DefSCZ) (a phenotype characterized by negative symptoms) is accompanied by activated immune-inflammatory pathways. A subset of patients with schizophrenia and DefSCZ experience physiosomatic symptoms reminiscent of chronic fatigue and fibromyalgia. However, there are no data whether, in DefSCZ, physiosomatic symptoms are associated with increased levels of cytokines/chemokines.

This study examined the associations between physiosomatic symptoms, as assessed with the FibroFatigue (FF) scale, and symptoms of DefSCZ as well as interleukin IL-1β, IL-1 receptor antagonist (sIL-1RA), tumor necrosis factor (TNF)-α and CCL11 (eotaxin) in 120 DefSCZ patients (as defined by the Schedule for Deficit Schizophrenia) and 54 healthy controls. In DefSCZ, there were robust associations between FF and negative symptoms, psychosis, hostility, excitation, mannerism, psychomotor retardation and formal thought disorders. A latent vector extracted from those DefSCZ symptom domains also loaded highly on the total FF score and showed adequate convergent validity, internal consistency reliability and predictive relevance. The FF score was significantly associated with impairments in semantic and episodic memory and executive functions. Soft Independent Modelling of Class Analogy showed that the FF items discriminated DefSCZ from controls with an 100% accuracy. Interleukin IL-1β, IL-1RA, TNF-α and CCL11 explained 59.4% of the variance in the LV extracted from the FF and DefSCZ symptoms.

In conclusion, these data show that physiosomatic symptoms are a core component of DefSCZ phenomenology and are strongly associated with activated immune pathways, which have neurotoxic effects.
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Paywall, https://www.sciencedirect.com/science/article/abs/pii/S0920996420302553
Sci hub, https://sci-hub.tw/10.1016/j.schres.2020.05.003

Snowdrop · May 30, 2020

Usual caveat about my limited knowledge and understanding.

If they really wanted to confirm that activation of immune pathways were happening wouldn't it be prudent to, rather than clinical assessments, investigate the biologic underpinnings at the cellular level?

I just don't see what value this type of research has to forwarding knowledge in any way.

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Chronic fatigue & fibromyalgia symptoms [] key components of deficit schizophrenia & [] associated w/activated immune-inflammatory.., 2020, Maes et al

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Chronic fatigue & fibromyalgia symptoms [] key components of deficit schizophrenia & [] associated w/activated immune-inflammatory.., 2020, Maes et al

Andy Committee Member

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