Brain fog during menopause? Here’s what’s really going on

Mij

Senior Member (Voting Rights)
New study links structural brain changes with cognitive, emotional, and physiological changes during menopause.

Evidence of Brain Recovery and Hormonal Adaptation
Increased white matter hyperintensities have also been documented across multiple studies, especially among women with early menopause or those with frequent hot flashes. White matter hyperintensities are bright spots seen on an MRI scan of the brain’s white matter, often indicating damaged tissue typically due to reduced blood flow. These lesions can lead to neurological symptoms like cognitive decline, balance issues, and mood changes and are associated with an increased risk of stroke and dementia.

Interestingly, some findings suggest that gray matter volume may partially recover after menopause, hinting at the brain's ability to adapt through neuroplasticity. Scientists have also observed higher estrogen receptor density during the menopause transition, which may reflect the brain's attempt to compensate for falling hormone levels. However, this increase has also been tied to weaker memory performance in some cases. Changes in blood vessel reactivity and energy metabolism within the brain further illustrate how menopause affects neural health and resilience.

Some evidence suggests a partial recovery of gray matter volume postmenopause, potentially reflecting compensatory neuroplastic processes. Additionally, elevated estrogen receptor density during the menopause transition may represent an adaptive response to declining hormone levels, although it has also been associated with poorer memory outcomes Alterations in cerebrovascular reactivity and brain energy metabolism further underscore the impact of menopause on neural integrity and functional resilience.

Unfortunately the link to the study doesn't work.
 
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