[Book] Long COVID Fatigue, 2025, Rudroff

forestglip · Apr 29, 2025 at 2:14 AM

Long COVID Fatigue - Clinical Sciences, Artificial Intelligence and the Future of Brain Health

Thorsten Rudroff

About this book
This book offers the first comprehensive analysis of long COVID fatigue using advanced neuroimaging and artificial intelligence (AI). It bridges the gap between basic science and patient care in post-viral syndromes. The volume guides readers from fundamental concepts to future innovations, making complex neurobiological mechanisms accessible to researchers and clinicians. Each chapter builds on the previous, connecting molecular mechanisms to clinical manifestations. The integration of AI in diagnosis and treatment is a pioneering approach in long COVID literature.

The book provides detailed analysis of brain metabolic patterns in long COVID fatigue, insights into protective mechanisms like metabolic heterogeneity in the basal ganglia, practical guidelines for AI-enhanced diagnostic and treatment approaches, and pathways for translating research into clinical practice. It combines rigorous scientific analysis with practical applications, serving as both a reference and a roadmap for future developments in long COVID research and treatment.

The main objectives are to provide a comprehensive understanding of long COVID fatigue mechanisms, present evidence-based approaches for diagnosis and treatment, showcase innovative AI applications in medical imaging, establish a framework for future research, and offer practical clinical management guidelines.

This book is tailored for neurologists, neuroscientists, COVID-19 specialists, radiologists, healthcare providers, AI researchers, and graduate students in related fields.

Link (Paywall)

forestglip · Apr 29, 2025 at 2:20 AM

Table of Contents

Front Matter (PDF)

“A Mysterious Malaise”

Understanding Fatigue

Factors Contributing to Long COVID Fatigue

Sex-Based Differences

Age-Related Considerations

Children and Long COVID Fatigue

The Science of Long COVID Fatigue

Cellular and Neurological Mechanisms in Long COVID Fatigue

Integration and Clinical Applications

Neuroimaging as a Window into Long COVID Fatigue

Neuroimaging Biomarkers in Long COVID Fatigue: Advanced Techniques and Clinical Applications

Risk Factors and Predictors of Long COVID Fatigue

Vaccination Status and Long COVID Fatigue

Diagnosis of Long COVID Fatigue

Core Treatment Approaches for Long COVID Fatigue

Pharmacological and Non-pharmacological Interventions

Revealing the Complexity of Long COVID Fatigue: Challenges and Promises of Artificial Intelligence

Final Remarks: Long COVID Fatigue in Brain Health Research: A Call to Action

Back Matter (PDF)

SNT Gatchaman · Apr 29, 2025 at 3:28 AM

Not all bad, but mostly not useful. And way too much BPS nonsense. Also trying to write a book when the subject is rapidly progressing means things will be quickly out-of-date.

Women report greater persisting neuropsychiatric symptoms than men, suggesting increased susceptibility to enduring COVID-19 neurological and mental health sequelae. Higher self-reported domestic stress among women further implicates home life strain in post-COVID fatigue. Similarly, women demonstrated more psychological effects following the 2003 SARS epidemic. Recent findings also associate absent social support in women with higher COVID-19-related post-traumatic stress, indicating greater stress reactivity. Previous cardiovascular research found marital and family stress strongly predicts female atherosclerosis development , underscoring the value of managing such stressors. Sex differences in symptom reporting and perception, which could impact interventions and studies, warrant consideration as well.

Biological sex also regulates depressive disorders and COVID-19 outcomes. Women face amplified pandemic-related risks like pre-existing anxiety, depression, chronic stress, and domestic violence. Severe initial COVID-19 commonly precedes longer-term neurological and psychiatric conditions, especially among women handling heightened childcare, home education, and family caretaking burdens.

Working mothers may also suffer career and development opportunity costs from increased family obligations. Isolated single women additionally confront pandemic-related economic anxieties and decreased social contact. Subsequent lifestyle changes like unhealthy diets, inactivity, and stress-linked eating/ drinking disproportionately predispose women to reliance on food cravings. Such cravings are associated with obesity itself conferring greater COVID-19 risk and inflammation. Besides acute myalgias, post-COVID musculoskeletal pain proves highly prevalent months later, with de novo symptoms in nearly 75% of those with prior complaints. History of similar pain, extended hospitalizations, headache, and female sex all independently associate with higher risk. Still, women simply perceive more pain than men overall.
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Among emerging therapeutic approaches for Long COVID fatigue, hyperbaric oxygen therapy has shown particular promise through rigorous clinical investigation. HBOT’s potential mechanism of action involves increasing oxygen delivery to tissues, modulating inflammatory responses, and promoting neuroplasticity. While preliminary studies suggested possible benefits, definitive evidence from controlled trials was initially lacking. However, recent research has now provided more substantial support for this intervention.

A new randomized, double-blind, sham-controlled clinical trial [62] has demonstrated promising results for hyperbaric oxygen therapy (HBOT) in treating post COVID-19 condition. The study, which included 73 patients with persistent symptoms for at least three months after COVID-19 infection, compared 40 daily sessions of HBOT (100% oxygen at 2 ATA) to a sham treatment (21% oxygen at 1.03 ATA).
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[62] is Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial (2022, Nature Scientific Reports)

but we now have Ten sessions of hyperbaric oxygen versus sham treatment in patients with long covid HOT-LoCO: a randomised, placebo-controlled, double-blind, phase II trial (2025, BMJ Open) which gave a null result.

Eleanor · Apr 29, 2025 at 9:51 AM

I'd bet money that the phrase "As a large language model" appears somewhere in there.

Hutan · Apr 29, 2025 at 11:59 AM

Severe initial COVID-19 commonly precedes longer-term neurological and psychiatric conditions, especially among women handling heightened childcare, home education, and family caretaking burdens.

Working mothers may also suffer career and development opportunity costs from increased family obligations. Isolated single women additionally confront pandemic-related economic anxieties and decreased social contact. Subsequent lifestyle changes like unhealthy diets, inactivity, and stress-linked eating/ drinking disproportionately predispose women to reliance on food cravings.
Click to expand...

Those damn working women running around dealing with all of their burdens. And those damn single women not running around and instead being too inactive, lolling on the couch and 'drinking disproportionately'. Somehow, that results in the working mothers and the single women ending up at the same point of Long covid.

Well, not all of them, not even all the ambition-thwarted working mothers or all of the anxious lonely single women. So, maybe there is something else going on?

Sex differences in symptom reporting and perception, which could impact interventions and studies, warrant consideration as well.
Click to expand...

Still, women simply perceive more pain than men overall.
Click to expand...

Perhaps regardless of how much homeschooling or at-home binge eating they do, the problem is women just whine way too much?

SNT Gatchaman said: ↑

Also trying to write a book when the subject is rapidly progressing means things will be quickly out-of-date.
Click to expand...

Umm. I think the 'Gender differences' chapter was probably out-of-date when it was written, possibly by a margin of some 100 years.

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[Book] Long COVID Fatigue, 2025, Rudroff

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