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Blood Test Predicts Onset of Rheumatoid Arthritis - Medscape - Jun 18, 2018.

Discussion in 'Other health news and research' started by Hutan, Sep 7, 2018.

  1. Hutan

    Hutan Moderator Staff Member

    Aotearoa New Zealand
    Article in Medscape

    The presence of at least five dominant B-cell receptor (BCR) clones in peripheral blood predicted the short-term onset of rheumatoid arthritis.

    The findings confirm results from a study of 21 people with autoantibodies indicating risk for rheumatoid arthritis (Ann Rheum Dis. 2017;76:1924-1930).

    "We think that peripheral BCR clones can be used to identify at-risk individuals who will go on to develop arthritis," Musters said in a statement. This information could be used to evaluate "early interventions to prevent the onset of disease."

    In their study, Musters and her colleagues used next-generation sequencing to evaluate BCR clones in 129 people with joint pain and rheumatoid arthritis-specific antibodies.

    Of these, 45 people tested positive— defined as at least five dominant BCR clones — and 84 tested negative.

    During the 104-month follow-up period, patients in the positive group were more likely to develop rheumatoid arthritis than those in the negative group (76% vs 13%; relative risk, 5.8; 95% confidence interval, 3.2 - 10.3; P < .0001).

    In addition, the more BCR clones, "the higher the risk of imminent-onset arthritis," he reported. Having nine or more dominant BCR clones in the blood corresponded with a positive predictive value of 91% for development within 3 years.
    Last edited: Sep 8, 2018
  2. Milo

    Milo Senior Member (Voting Rights)

  3. Snow Leopard

    Snow Leopard Senior Member (Voting Rights)

    Would be interesting to see if this is also associated with the early/acute development of other autoimmune diseases.

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