Baricitinib Trial Poll

[Jaybee00]

Please see thread here

https://www.s4me.info/threads/reverse-long-covid-19-with-baricitinib-study-reverse-lc.36979/

Is the Baricitinib trial worth doing? Is it worth spending $30 million USD on the trial?

 

[Yann04]

Have their been any published smaller-scale trials showing promise?

 

[RedFox]

We need a drug badly and we should try anything.

 

[Jaybee00]

This must be the pilot scale study?

Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813065/

 

[forestglip]

Have their been any published smaller-scale trials showing promise?

One two person LC case report I found on Twitter. Most evidence seems to be about acute COVID.

https://www.s4me.info/threads/rever...ricitinib-study-reverse-lc.36979/#post-536631

 

[EndME]

This must be the pilot scale study?

Efficacy and safety of baricitinib plus standard of care for the treatment of critically ill hospitalised adults with COVID-19 on invasive mechanical ventilation or extracorporeal membrane oxygenation: an exploratory, randomised, placebo-controlled trial



https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8813065/

No this is the trial for acute Covid-19 by Wes Ely. According to Ely, Baricitinib is one of the most effective drugs for severe acute Covid and that surely played some role in them hoping it would work in LC. He has presented his thoughts in some interviews/conferences but I can't claim to have understood the narrative to trial Baricitinib in LC.

 

[forestglip]

https://twitter.com/user/status/1521105261699780609


REVERSE-LC was originally a pilot study and they converted it:
https://twitter.com/user/status/1733602591903301692

 

[Jaybee00]

OK I’m still confused. Did he have some promising data from his pilot study?

FWIW, I voted for conducting a Baricitinib trial at a lower funding level. A $30 million dollar trial would be the largest drug trial for LC +MECFS maybe by an order of magnitude. Maybe the Fluge phase 3 ritux would be the largest before this?

 

[EndME]

OK I’m still confused. Did he have some promising data from his pilot study?

FWIW, I voted for conducting a Baricitinib trial at a lower funding level. A $30 million dollar trial would be the largest drug trial for LC +MECFS maybe by an order of magnitude. Maybe the Fluge phase 3 ritux would be the largest before this?

There's a Baricitinib thread here. From what I've understood there was no pilot study. The initial plan was to do a smaller study/pilot study but they eventually got a sufficiently large grant and decided to directly go for a big study.