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Azlocillin can be the potential drug candidate against drug-tolerant Borrelia burgdorferi sensu stricto JLB31. 2020, Pothineni et al

Discussion in 'Infections: Lyme, Candida, EBV ...' started by Andy, Mar 19, 2020.

  1. Andy

    Andy Committee Member (& Outreach when energy allows)

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    Location:
    Hampshire, UK
    Open access, https://www.nature.com/articles/s41598-020-59600-4
     
    dadouv47, shak8, alktipping and 3 others like this.
  2. 5vforest

    5vforest Senior Member (Voting Rights)

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    Location:
    San Francisco, CA
    There are a lot of people suffering from chronic Lyme Disease who are banking on Azlocillin being a silver bullet cure. I am pretty skeptical.

    I am really unclear as to why Azlocillin was chosen in this study, besides the fact that the researchers have a patent for its reformulation into an oral drug.

    There are probably a lot of compounds that will eradicate Bb in vitro. Remember, Disulfiram was said to do this as well, and it's already available for use. But there are a lot of people who remain sick, with some evidence of persistent infection, despite a course of Dilsulfiram.

    There are a lot of remaining questions for those of us suffering with chronic effects of tick borne infections and I am dubious that Azlocillin is going to change much.
     

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