Autoimmune therapies: an inspiration for anti-aging therapies?

Jaybee00 said:
Highly speculative post: Autoimmune diseases have benefitted from a repurposing of modalities from blood malignancies. Imo, once we find the immune cell subpopulations driving age-related diseases, we'll see repurposing from autoimmune -> aging
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Yer, well, that occurred to Jo C and I in 2000 - 25 years ago - and we went around saying we should all have a shot of ritux to ensure eternal youth. (I guess Ruxandra might have been in nappies then.) Things ain't quite that simple though!!

It may be a bit like jogging - it probably prolongs your life for exactly the length of time you are in misery running up and down - or sitting having your ritux infusions.

Why don't people read the literature?
 
Aren't most age-related disease due to telomeres reaching their "no more replacement" limit? Well, there's also accumulated debris and damage that doesn't have a mechanism for repair or doesn't get recognized as needing replacement of the whole cell.
 
Creekside said:
Aren't most age-related disease due to telomeres reaching their "no more replacement" limit? Well, there's also accumulated debris and damage that doesn't have a mechanism for repair or doesn't get recognized as needing replacement of the whole cell.
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That’s one of the things associated with aging. My former rotation lab also did some interesting work associating the length of a gene with abnormalities in aging—the idea being that all transcriptional machinery seems to become less efficient with age, so longer genes have more opportunities to go wrong and never become a functional protein.

This could have all sorts of other downstream effects. There’s also epigenetic changes associated with aging, changes in immune cells, some changes in mTOR signaling (that have yet to be fruitful) etc. etc. etc. Long story short, there’s no short story
 
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